Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 20/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 19/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344811 | 0.92 | MTNR1A (0.64) | MTNR1AMTNR1BKDM4EMEN1ALDH1A1 | |
| SCHEMBL5340177 | 0.86 | MTNR1A (0.55) | MTNR1AMTNR1BALDH1A1NQO2 | |
| SCHEMBL5344738 | 0.84 | MTNR1A (0.74) | MTNR1AMTNR1BKDM4EMEN1ALDH1A1 | |
| SCHEMBL7018000 | 0.84 | MTNR1A (0.74) | MTNR1AMTNR1BKDM4EMEN1ALDH1A1 | |
| SCHEMBL5346659 | 0.82 | MTNR1A (0.66) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7015312 | 0.80 | MTNR1A (0.67) | MTNR1AMTNR1BKDM4EMEN1ALDH1A1 | |
| SCHEMBL7016697 | 0.80 | MTNR1A (0.70) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL7015011 | 0.80 | MTNR1A (0.76) | MTNR1AMTNR1B | |
| SCHEMBL8135627 | 0.80 | MTNR1A (1.00) | MTNR1AMTNR1BKDM4EMEN1ALDH1A1 | |
| SCHEMBL5348439 | 0.78 | MTNR1A (0.56) | MTNR1AMTNR1BKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123529-A1 | Substituted biphenyl compounds | LES LABORATOIRES SERVIER (FR) | 2007-05-31 | — | — | US | disclosed |
| US-7161035-B2 | Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-01-09 | — | — | US | disclosed |
| US-20040014969-A1 | Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014969-A1 | Substituted biphenyl derivatives, method for preparing same and pharmaceutical compositions containing same | MTNR1A, MTNR1B, MC2R | MTNR1A 1/4885MTNR1B 2/4885KDM4E 3227/4885 |
| US-20070123529-A1 | Substituted biphenyl compounds | MTNR1A, MTNR1B, CNR1 | MTNR1A 1/4885MTNR1B 2/4885KDM4E 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.