Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.49 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5345575 | 1.00 | GRIK1 (0.49) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29378321 | 0.87 | LDHA (0.60) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29965330 | 0.87 | LDHA (0.60) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL28741565 | 0.86 | LDHA (0.59) | LDHAHTTLMNAMAPK1RAB9A | |
| SCHEMBL8012680 | 0.86 | LDHA (0.59) | LDHAHTTLMNAMAPK1RAB9A | |
| SCHEMBL31329364 | 0.86 | LDHA (0.59) | LDHAHTTLMNAMAPK1RAB9A | |
| SCHEMBL5345434 | 0.85 | TAS1R3 (0.46) | HTTLMNAKDM4EMITFALDH1A1 | |
| SCHEMBL25177926 | 0.85 | GRIK1 (0.48) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL25177927 | 0.85 | GRIK1 (0.48) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL25186372 | 0.84 | GRIK1 (0.47) | GRIK1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113692401-A | Process for producing aromatic amino acid derivative | 中外制药株式会社 | 2021-11-23 | — | — | CN | disclosed |
| US-7169808-B2 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-01-30 | — | — | US | disclosed |
| US-20030195257-A1 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNTE S.P.A. (IT) | 2003-10-16 | — | — | US | disclosed |
| EP-1292563-A2 | COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2003-03-19 | — | — | EP | disclosed |
| WO-2002000593-A2 | COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195257-A1 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | PDE3A, PDE5A, PDE3B | GRIK1 2668/4885GRIA1 3204/4885GRIA2 4232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.