Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2959935 | 0.77 | — | — | |
| SCHEMBL355335 | 0.69 | — | — | |
| Hydrazinecarboxamide SCHEMBL5345890 | 0.68 | TSHR (0.67) | CYP1A2TSHRNFKB1MAOAMAOB | |
| SCHEMBL28351305 | 0.68 | LMNA (0.39) | CYP1A2TSHRNFKB1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL28265875 | 0.67 | — | — | |
| SCHEMBL2782941 | 0.67 | — | — | |
| SCHEMBL21785 | 0.66 | — | — | |
| SCHEMBL5873290 | 0.65 | — | — | |
| SCHEMBL2136922 | 0.65 | — | — | |
| SCHEMBL27676666 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235671-B2 | Process for preparing 3-chloromethyl-1,2,4-triazolin-5-one | MERCK & CO. INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-20060052355-A1 | reacting a chloro contaiing triaryl- or trialkyl-orthoester with a sulfonic acid salt of semicarbazide in an organic solvent, adding a brine solution to the concentrated reaction mixture,cooling the mixture to form a solid product, acidification with aqueous acid | MERCK SHARP & DOHME CORP. | 2006-03-09 | — | — | US | disclosed |
| EP-1549623-A4 | PROCESS FOR PREPARING 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE | MERCK & CO INC (US) | 2005-10-05 | — | — | EP | disclosed |
| EP-1549623-A2 | PROCESS FOR PREPARING 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE | Merck & Co., Inc. (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004017898-A2 | PROCESS FOR PREPARING 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE | MERCK & CO., INC. (US) | 2004-03-04 | — | — | WO | disclosed |
| US-5641796-A | PHENYL-OXAZOLYL-ALKYLOXY OR THIO-PHENYLALKYL TRIAZOLINE-3-ONE OR THIONE ANTIDIABETIC AGENT | ELI LILLY AND COMPANY (US) | 1997-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052355-A1 | reacting a chloro contaiing triaryl- or trialkyl-orthoester with a sulfonic acid salt of semicarbazide in an organic solvent, adding a brine solution to the concentrated reaction mixture,cooling the mixture to form a solid product, acidification with aqueous acid | CLIC1, CTRC, NISCH | CYP1A2 1372/4885TSHR 967/4885NFKB1 2444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.