Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 16/20 | 0.65 |
| ▸ | IL1B | P01584 | 4/20 | 0.65 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27473868 | 0.82 | GAA (0.40) | CASP1IL1B | |
| SCHEMBL27551611 | 0.82 | CASP1 (0.65) | CASP1IL1BCAPN1 | |
| SCHEMBL4456720 | 0.79 | CASP1 (1.00) | CASP1IL1BCAPN1 | |
| SCHEMBL27459599 | 0.73 | CASP1 (0.37) | CASP1IL1B | |
| SCHEMBL27551609 | 0.69 | CASP1 (1.00) | CASP1IL1B | |
| SCHEMBL12914538 | 0.69 | CASP1 (1.00) | CASP1IL1B | |
| SCHEMBL27476202 | 0.69 | GAA (0.40) | — | |
| SCHEMBL7443313 | 0.68 | CASP1 (0.59) | CASP1IL1BCAPN1 | |
| SCHEMBL7431065 | 0.66 | CASP1 (0.63) | CASP1IL1B | |
| SCHEMBL15444282 | 0.66 | CASP1 (0.52) | CASP1IL1BCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288624-B2 | Inhibitors of interleukin-1β converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-30 | — | — | US | disclosed |
| US-20020099042-A1 | Inhibitors of interleukin-1 beta converting enzyme | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-25 | — | — | US | disclosed |
| US-6420522-B1 | ENZYME INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099042-A1 | Inhibitors of interleukin-1 beta converting enzyme | IL1B, IL1A, IL1RN | CASP1 6/4885IL1B 1/4885CAPN1 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.