Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 10/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 3/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29045424 | 0.81 | FFAR1 (0.46) | FFAR1MTNR1AMPOFFAR4TLR8 | |
| SCHEMBL30828055 | 0.75 | TAAR1 (0.53) | FFAR1MTNR1AMPOFFAR4TLR8 | |
| SCHEMBL6800944 | 0.74 | MTNR1A (0.40) | FFAR1MTNR1AMPOFFAR4MAPK1 | |
| SCHEMBL27530341 | 0.73 | TAAR1 (0.55) | MTNR1AMPOSLC6A4ALDH1A1 | |
| SCHEMBL3790529 | 0.73 | FDPS (0.44) | MTNR1AMPOTLR8ATMSLC6A4 | |
| SCHEMBL517084 | 0.72 | CYP4F2 (0.49) | MTNR1AMPOTLR8HDAC1HDAC2 | |
| SCHEMBL5878486 | 0.72 | CYP4F2 (0.49) | MTNR1AMPOTLR8HDAC1HDAC2 | |
| SCHEMBL29407477 | 0.72 | CYP4F2 (0.49) | MTNR1AMPOTLR8HDAC1HDAC2 | |
| SCHEMBL9395052 | 0.72 | CYP4F2 (0.49) | MTNR1AMPOTLR8HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL10784054 | 0.72 | FDPS (0.43) | MTNR1AMPOTLR8ATMSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |