Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325655 | 0.88 | ALDH1A1 (0.64) | LMNATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL5323167 | 0.85 | PKM (0.64) | LMNAL3MBTL1USP2TSHRTDP1 | |
| SCHEMBL5349081 | 0.85 | TSHR (0.55) | LMNAL3MBTL1TSHRALDH1A1MEN1 | |
| SCHEMBL16707660 | 0.85 | MEN1 (0.55) | LMNAL3MBTL1TDP1ALDH1A1MEN1 | |
| SCHEMBL5455187 | 0.83 | KDM4E (0.61) | LMNAL3MBTL1HTTPOLBGAA | |
| SCHEMBL3216015 | 0.83 | ALDH1A1 (0.62) | LMNATSHRTDP1ALDH1A1MEN1 | |
| SCHEMBL17029173 | 0.82 | LMNA (0.50) | LMNAALDH1A1MEN1KMT2AHTT | |
| SCHEMBL5323174 | 0.81 | MCOLN3 (0.60) | LMNATSHRMEN1KMT2AHTT | |
| SCHEMBL5352439 | 0.79 | MCOLN3 (0.50) | LMNAL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL5331427 | 0.79 | CHRM4 (0.48) | LMNAL3MBTL1TSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | claimed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |