Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533275 | 0.81 | PRNP (0.42) | PLAUHPGDCYP3A4HTTDYRK1A | |
| SCHEMBL31378698 | 0.79 | PLAU (0.36) | PLAUHPGDHTTDYRK1ANPSR1 | |
| SCHEMBL1926191 | 0.78 | DYRK1A (0.33) | HPGDHTTDYRK1ALMNAPRNP | |
| SCHEMBL2316611 | 0.78 | HSD17B10 (0.37) | HPGDHSD17B10CYP3A4CRHBPCRHR2 | |
| SCHEMBL1927586 | 0.78 | ESR1 (0.33) | HPGDHTTDYRK1ALMNAPRNP | |
| SCHEMBL534655 | 0.78 | HTT (0.40) | HPGDCYP3A4HTTDYRK1ALMNA | |
| SCHEMBL1361039 | 0.78 | DYRK1A (0.40) | PLAUHPGDHSD17B10CYP3A4HTT | |
| SCHEMBL3100730 | 0.74 | ESR1 (0.33) | HPGDHSD17B10HTTDYRK1ALMNA | |
| SCHEMBL5558125 | 0.72 | NR4A2 (0.38) | PLAULMNAALDH1A1MAPT | |
| SCHEMBL1927481 | 0.70 | PLAU (0.35) | PLAUHTTDYRK1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022128746-A1 | QUINOLINE DERIVATIVES AS ENDOPARASITICIDES | ELANCO TIERGESUNDHEIT AG (CH) | 2022-06-23 | — | — | WO | disclosed |
| US-8440595-B2 | Fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-05-14 | — | — | US | disclosed |
| CN-101827817-B | Saturated and insaturated bi- or tricyclic aryloxyacetamide derivatives and their use as fungicides | SYNGENTA CROP PROTECTION LLC | 2013-05-08 | — | — | CN | disclosed |
| EP-2185518-B1 | Aryloxyacetamide derivatives and their use as fungicides | SYNGENTA PARTICIPATIONS AG (CH) | 2012-02-08 | — | — | EP | disclosed |
| US-8067592-B2 | N-alkyny-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | SYNGENTA LIMITED (GB) | 2011-11-29 | — | — | US | disclosed |
| EP-2185519-B1 | NOVEL FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-08-10 | — | — | EP | disclosed |
| CN-101115748-B | Acetamide compounds as fungicides | SYNGENTA PARTICIPATIONS AG | 2011-06-08 | — | — | CN | disclosed |
| US-7956188-B2 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2011-06-07 | — | — | US | disclosed |
| US-20100286199-A1 | NOVEL FUNGICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-11 | — | — | US | disclosed |
| EP-1638928-B1 | N-ALKYNYL-2-(SUBSTITUTED ARYLOXY)ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | SYNGENTA LTD (GB) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009049716-A2 | NOVEL FUNGICIDES | SYGENTA PARTICIPATIONS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009030467-A2 | SATURATED AND INSATURATED BI- OR TRICYCLIC ARYLOXYACETAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG, (CH) | 2009-03-12 | — | — | WO | disclosed |
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | SYNGENTA CROP PROTECTION, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| CN-101115748-A | Acetamide compounds as fungicides | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-30 | — | — | CN | disclosed |
| EP-1817309-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | Syngeta Participations AG (CH) | 2007-08-15 | — | — | EP | disclosed |
| US-20070042996-A1 | N-alkynyl-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | SYNGENTA LIMITED (GB) | 2007-02-22 | — | — | US | disclosed |
| CN-1812966-A | N-alkynyl-2- (substituted aryloxy) alkylthioamide derivatives as fungicides | SYNGENTA LTD (GB) | 2006-08-02 | — | — | CN | disclosed |
| WO-2006058700-A1 | ACETAMIDE COMPOUNDS AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2006-06-08 | — | — | WO | disclosed |
| EP-1638928-A1 | N-ALKYNYL-2-(SUBSTITUTED ARYLOXY)ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | Syngenta Limited (GB) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004108663-A1 | N-ALKYNYL-2- (SUBSTITUTED ARYLOXY) ALKYLTHIOAMIDE DERIVATIVES AS FUNGICIDES | SYNGENTA LIMITED (GB) | 2004-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171767-A1 | N-substituted-2-alkylthio-2-(substituted aryloxy and heteroaryloxy)alkylamides and their sulphinyl and sulphonyl derivatives such as 2-(3,5-dichlorophenoxy)-2-methylthio-N-2-methylprop-2-yl acetamide; fungal infections of plants | NAT1, DPM1, AADAC | PLAU 4885/4885HPGD 4169/4885HSD17B10 1896/4885 |
| US-20100286199-A1 | NOVEL FUNGICIDES | CYP51A1, CYP4X1, CYP1B1 | PLAU 4883/4885HPGD 4633/4885HSD17B10 312/4885 |
| US-20070042996-A1 | N-alkynyl-2-(substituted aryloxy) alkylthioamine derivatives as fungicides | NAT1, AKR7A2, KCNA2 | PLAU 4849/4885HPGD 4720/4885HSD17B10 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.