Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MYC | P01106 | 4/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1280419 | 0.90 | ALDH1A1 (0.54) | ALDH1A1ALOX15L3MBTL1GAAMYC | |
| SCHEMBL31056512 | 0.88 | APOBEC3A (0.52) | ALDH1A1ALOX15L3MBTL1GAAMYC | |
| SCHEMBL6715699 | 0.81 | NPC1 (0.53) | ALDH1A1ALOX15L3MBTL1MYCNR4A1 | |
| SCHEMBL31218916 | 0.80 | TNKS (0.63) | ALDH1A1ALOX15L3MBTL1GAATNKS | |
| SCHEMBL28794911 | 0.80 | HTR6 (0.41) | ALDH1A1L3MBTL1MYCNR4A1POLB | |
| SCHEMBL9262225 | 0.78 | GAA (0.55) | ALDH1A1ALOX15L3MBTL1GAAMYC | |
| SCHEMBL7931306 | 0.76 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1GAAMYCNR4A1 | |
| SCHEMBL17893580 | 0.75 | ALDH1A1 (0.50) | ALDH1A1ALOX15L3MBTL1GAAMYC | |
| SCHEMBL8048603 | 0.75 | ALDH1A1 (0.61) | ALDH1A1ALOX15L3MBTL1MYCNR4A1 | |
| SCHEMBL31518544 | 0.75 | L3MBTL1 (0.49) | ALDH1A1ALOX15L3MBTL1GAAMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861396-A1 | TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY | AstraZeneca AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006092608-A1 | TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2006-09-08 | — | — | WO | disclosed |