Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6235584 | 0.90 | LMNA (0.62) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL5200654 | 0.88 | LMNA (0.52) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL14375419 | 0.86 | LMNA (0.66) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL25367964 | 0.85 | LMNA (0.48) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL25367915 | 0.84 | LMNA (0.47) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL25368425 | 0.81 | CYP1A2 (0.46) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL26113879 | 0.81 | CHEK2 (0.47) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL26115255 | 0.80 | LMNA (0.47) | LMNAMEN1KMT2ACYP1A2NR1I2 | |
| SCHEMBL5342617 | 0.80 | KDR (0.47) | LMNAMEN1KMT2ACYP3A4NPC1 | |
| SCHEMBL25370002 | 0.79 | MEN1 (0.44) | LMNAMEN1KMT2ACYP1A2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249600-A1 | CHEMICAL COMPOUNDS | CHEUNG MUI | 2007-10-25 | — | — | US | disclosed |
| US-7238813-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-20040082583-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249600-A1 | CHEMICAL COMPOUNDS | TIE1, KDR, FLT4 | LMNA 2801/4885MEN1 760/4885KMT2A 165/4885 |
| US-20040082583-A1 | Chemical compounds | TIE1, KDR, FLT4 | LMNA 2801/4885MEN1 760/4885KMT2A 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.