Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 6/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | F9 | P00740 | 4/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5347580 | 1.00 | CIT (0.36) | CITPIK3C3FLT3SYKTP53 | |
| SCHEMBL5351129 | 0.89 | MAPT (0.42) | CITPIK3C3TP53MAPTF9 | |
| SCHEMBL8358821 | 0.85 | ROCK2 (0.38) | PIK3C3TP53 | |
| SCHEMBL2073081 | 0.84 | F10 (0.39) | CITF9FFAR1F10F2 | |
| SCHEMBL5735438 | 0.84 | DOT1L (0.37) | CITMAPTF9F10F2 | |
| SCHEMBL2071990 | 0.83 | F9 (0.42) | CITMAPTCRHR1F9F10 | |
| SCHEMBL2070985 | 0.81 | F10 (0.52) | F9F10 | |
| SCHEMBL2073265 | 0.81 | F10 (0.52) | F9F10 | |
| SCHEMBL5735355 | 0.81 | CIT (0.35) | CITMAPTF9F10F2 | |
| SCHEMBL5735353 | 0.81 | CIT (0.35) | CITMAPTF9F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199133-B2 | Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors | MERCK PATENT GESELLSCHAFT (DE) | 2007-04-03 | — | — | US | claimed |
| EP-1441726-B1 | DERIVATIVES OF PHENOXY-N-'4-(ISOTHIAZOLIDIN-1,1-DIOXID-2YL)PHENY]-VALERIAN- ACID AMIDE AND OTHER COMPOUNDS AS INHIBITORS OF THE COAGULATION FACTOR XA IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMORS | MERCK PATENT GMBH (DE) | 2006-12-20 | — | — | EP | claimed |
| US-20040254175-A1 | Derivatives of phenoxy-n-'4-(isothiazolindin-1,1-dioxid-2yl)phenyl!-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors | MERCK PATENT GMBH (DE) | 2004-12-16 | — | — | US | claimed |
| US-7199133-B2 | Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors | MERCK PATENT GESELLSCHAFT (DE) | 2007-04-03 | — | — | US | disclosed |
| US-7199133-B2 | Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors | MERCK PATENT GESELLSCHAFT (DE) | 2007-04-03 | — | — | US | disclosed |
| US-7199133-B2 | Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors | MERCK PATENT GESELLSCHAFT (DE) | 2007-04-03 | — | — | US | disclosed |
| US-20040254175-A1 | Derivatives of phenoxy-n-'4-(isothiazolindin-1,1-dioxid-2yl)phenyl!-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors | MERCK PATENT GMBH (DE) | 2004-12-16 | — | — | US | disclosed |
| WO-2003039543-A1 | DERIVATIVES OF PHENOXY-N-'4-(ISOTHIAZOLIDIN-1,1-DIOXID-2YL)PHENY!-VALERIAN- ACID AMIDE AND OTHER COMPOUNDS AS INHIBITORS OF THE COAGULATION FACTOR XA IN THE TREATMENT OF THROMBOEMBOLIC DISEASES AND TUMORS | MERCK PATENT GMBH (DE) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254175-A1 | Derivatives of phenoxy-n-'4-(isothiazolindin-1,1-dioxid-2yl)phenyl!-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors | F2, F11, SERPINC1 | CIT 2412/4885PIK3C3 1279/4885FLT3 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.