Methane

Methane

SCHEMBL534895

C.COC(=O)C(=CC(=O)O)c1ccccc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
KDM4E B2RXH2 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ALDH1A1 P00352 5/20 0.42
HPGD P15428 2/20 0.42
HTT P42858 2/20 0.42
MAPT P10636 4/20 0.41
LMNA P02545 3/20 0.41
GAA P10253 1/20 0.41
HDAC3 O15379 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
IDO1 P14902 1/20 0.41
ALOX15 P16050 1/20 0.41
HDAC1 Q13547 1/20 0.41
CA9 Q16790 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4007052 0.98 TSHR (0.50) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL4007049 0.98 TSHR (0.50) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL77733 0.85 TSHR (0.48) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL4732473 0.85 NFE2L2 (0.52) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL3681269 0.85 TSHR (0.48) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL6394005 0.85 TSHR (0.48) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL1983412 0.84 ALDH1A1 (0.60) KDM4ESMN1; SMN2TDP1ALDH1A1HPGD
SCHEMBL2048794 0.82 TSHR (0.54) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL4013088 0.82 TSHR (0.54) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1
SCHEMBL7807838 0.82 TSHR (0.54) TSHRKDM4ESMN1; SMN2TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2415794-A1 CURABLE COMPOSITION AND CURED PRODUCT THEREOF Showa Denko K.K. (JP) 2012-02-08 EP disclosed
US-20120010361-A1 CURABLE COMPOSITION AND CURED PRODUCT THEREOF SHOWA DENKO K.K. (JP) 2012-01-12 US disclosed
US-7138478-B2 Process for mixing polymer melts with additives BAYER AKTIENGESELLSCHAFT (DE) 2006-11-21 US disclosed
US-20050121817-A1 Process for mixing polymer melts with additives BAYER MATERIALSCIENCE AG (DE) 2005-06-09 US disclosed
US-20040225103-A1 Process for mixing polymer melts with additives COVESTRO DEUTSCHLAND AG (DE) 2004-11-11 US disclosed
US-6699959-B2 EXHIBITS A FLOW BEHAVIOR SIMILAR TO THAT OF A LINEAR POLYCARBONATE OF COMPARABLE MOLECULAR WEIGHT OBTAINED BY THE INTERFACE POLYMERIZATION PROCESS. BAYER AKTIENGESELLSCHAFT (DE) 2004-03-02 US disclosed
US-20030027973-A1 Polycarbonate having a low shear thinning behavior BAYER AKTIENGESELLSCHAFT (DE) 2003-02-06 US disclosed