SCHEMBL5348965

SCHEMBL5348965

O=CN1CCOC(c2ccc3nc(-c4ccc(Cl)cc4)c(-c4ccc(Cl)cc4)n3c2)C1

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 12/20 0.45
AKT1 P31749 2/20 0.41
AKT2 P31751 2/20 0.41
SLC2A2 P11168 3/20 0.40
KDM4E B2RXH2 1/20 0.39
HTT P42858 1/20 0.39
KCNK3 O14649 1/20 0.38
KCNK9 Q9NPC2 1/20 0.38
ALOX5 P09917 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4125324 0.72 GSK3B (0.40)
SCHEMBL4256479 0.67 CHRNB2 (0.37)
SCHEMBL17718916 0.66 SLC2A1 (0.72) SLC2A1SLC2A2
SCHEMBL295269 0.66 CNR2 (0.46)
SCHEMBL5345220 0.65 KDM4E (0.59) SLC2A1SLC2A2KDM4EHTT
SCHEMBL1633511 0.65 DRD3 (0.36)
SCHEMBL3120324 0.65 NPC1 (0.36)
SCHEMBL17061071 0.65 CCNC (0.37)
SCHEMBL15288208 0.65 MKNK1 (0.35)
SCHEMBL5348158 0.64 AKT1 (0.60) AKT1AKT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007086080-A2 NOVEL IMIDAZO[1,2-a]PYRIDINE CANNABINOID RECEPTOR LIGANDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM GLENMARK PHARMACEUTICALS LIMITED (IN) 2007-08-02 WO claimed