Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 11/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334028 | 0.93 | HTR4 (0.57) | HTR4CYP3A4ACHEDCPSHCRTR2 | |
| SCHEMBL5341243 | 0.91 | HTR4 (0.60) | HTR4CYP3A4ACHEKCNH2 | |
| SCHEMBL5120856 | 0.90 | HTR4 (0.60) | HTR4CYP3A4ACHEDRD3DCPS | |
| SCHEMBL5346572 | 0.89 | HTR4 (0.62) | HTR4CYP3A4ACHEKCNH2 | |
| SCHEMBL5119519 | 0.85 | HTR4 (0.60) | HTR4CYP3A4ACHEDRD3DCPS | |
| SCHEMBL5394346 | 0.84 | HTR4 (0.55) | HTR4CYP3A4ACHE | |
| SCHEMBL5114319 | 0.84 | HTR4 (0.66) | HTR4CYP3A4ACHEDCPSHCRTR2 | |
| SCHEMBL5348518 | 0.84 | HTR4 (0.53) | HTR4CYP3A4ACHEDRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL17275530 | 0.83 | HTR4 (0.65) | HTR4CYP3A4ACHEDCPSHCRTR2 | |
| SCHEMBL17275529 | 0.83 | HTR4 (0.65) | HTR4CYP3A4ACHEDCPSHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856114-A1 | BENZISOXAZOLE DERIVATIVES | Pfizer, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006090224-A1 | BENZISOXAZOLE DERIVATIVES | PFIZER JAPAN INC. (JP) | 2006-08-31 | — | — | WO | disclosed |