SCHEMBL5350756

SCHEMBL5350756

CCCC(Cc1ccc(OCCCCOCc2ccccc2)nc1NC(=O)C(C)(C)C)OC

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MMP3 P08254 5/20 0.35
MMP8 P22894 4/20 0.35
MMP1 P03956 4/20 0.35
MMP9 P14780 3/20 0.35
FGFR1 P11362 3/20 0.34
KDR P35968 3/20 0.34
JAK2 O60674 1/20 0.34
L3MBTL1 Q9Y468 3/20 0.34
PTGES O14684 3/20 0.33
ALOX5 P09917 3/20 0.33
PPARG P37231 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5372256 0.82 L3MBTL1 (0.38) MMP3MMP8MMP1MMP9FGFR1
SCHEMBL247076 0.77 L3MBTL1 (0.39) MMP3MMP8MMP1MMP9FGFR1
SCHEMBL5374444 0.77 L3MBTL1 (0.46) FGFR1KDRJAK2L3MBTL1
SCHEMBL5218282 0.76 FGFR1 (0.36) MMP3MMP8MMP1MMP9FGFR1
SCHEMBL5218290 0.76 FGFR1 (0.36) MMP3MMP8MMP1MMP9FGFR1
SCHEMBL247864 0.73 AKR1B10 (0.36) FGFR1KDRJAK2L3MBTL1ALOX5
SCHEMBL5191114 0.63 NOX1 (0.45) L3MBTL1PPARG
SCHEMBL14991781 0.62 FOLH1 (0.47)
SCHEMBL25120992 0.61 MMP3 (0.50) MMP3MMP8MMP1MMP9L3MBTL1
Methyl Carbamate SCHEMBL3929301 0.61 CETP (0.51) L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007116265-A1 PROCESS FOR MAKING A TETRAHYDRO-PYRIDOAZEPIN-8-ONE COMPOUND PFIZER PRODUCTS INC. (US) 2007-10-18 WO disclosed