Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGAV | P06756 | 2/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | DDX3X | O00571 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6543559 | 0.87 | KMT2A (0.52) | MEN1KMT2APKMMAPTLPAR1 | |
| SCHEMBL7079595 | 0.85 | HIF1A (0.60) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL6542890 | 0.83 | MEN1 (0.46) | MEN1KMT2AGAAPKMMAPT | |
| SCHEMBL5991743 | 0.81 | PTGS2 (0.63) | PTGS2MEN1KMT2AGAAMAPT | |
| SCHEMBL6257325 | 0.78 | ITGA4 (0.44) | MEN1KMT2AGAAPKMMAPT | |
| SCHEMBL4683165 | 0.77 | ITGA4 (0.67) | MEN1KMT2AGAAMAPTPOLB | |
| SCHEMBL20540167 | 0.76 | KMT2A (0.61) | MEN1KMT2AGAAPKMMAPT | |
| SCHEMBL5273139 | 0.74 | NR3C2 (0.45) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL7798245 | 0.74 | HSD17B10 (0.53) | PTGS2MEN1KMT2AMAPTPOLB | |
| SCHEMBL5157330 | 0.74 | MAPT (0.56) | MEN1KMT2AGAAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211586-B2 | Substituted tetrahydroisoquinolines | AVENTIS PHARMA LIMITED (GB) | 2007-05-01 | — | — | US | disclosed |
| EP-1392306-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | Aventis Pharma Limited (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002098426-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES | AVENTIS PHARMA LIMTIED (GB) | 2002-12-12 | — | — | WO | disclosed |