Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.45 |
| ▸ | FEN1 | P39748 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 10/20 | 0.43 |
| ▸ | ATM | Q13315 | 6/20 | 0.43 |
| ▸ | PRKDC | P78527 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15406716 | 0.83 | MKNK1 (0.49) | MKNK1MKNK2ALOX5APFEN1PTGS2 | |
| SCHEMBL5350907 | 0.83 | PTGS2 (0.63) | MKNK1MKNK2PTGS2PTGS1MAP4K4 | |
| SCHEMBL8029364 | 0.81 | CA2 (0.61) | MKNK1MKNK2PTGS2PTGS1MAP4K4 | |
| SCHEMBL27928727 | 0.80 | MKNK1 (0.53) | MKNK1MKNK2PTGS2PTGS1MAP4K4 | |
| SCHEMBL30139292 | 0.78 | ATR (0.47) | ATRATMPRKDCGSK3B | |
| SCHEMBL758098 | 0.78 | CA12 (0.49) | PTGS2PTGS1ATRATMPRKDC | |
| SCHEMBL624495 | 0.76 | MKNK1 (0.54) | MKNK1MKNK2MAP4K4 | |
| SCHEMBL14555429 | 0.74 | CA2 (0.60) | PTGS2PTGS1CA12CA1CA2 | |
| SCHEMBL4582572 | 0.73 | MKNK1 (0.59) | MKNK1MKNK2MAP4K4 | |
| SCHEMBL624800 | 0.72 | MAP4K4 (0.55) | MKNK1MKNK2ALOX5APFEN1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |