SCHEMBL535128

SCHEMBL535128

NC(c1ccccc1)[C@H]1CC[C@H]1C(=O)NC1CCc2ccccc2N1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.43
CYP2D6 P10635 3/20 0.43
CYP1A2 P05177 2/20 0.43
TSHR P16473 2/20 0.43
MAPK1 P28482 1/20 0.43
HSD17B10 Q99714 1/20 0.43
SMYD3 Q9H7B4 1/20 0.43
MTNR1A P48039 3/20 0.37
GAA P10253 2/20 0.34
MAPT P10636 1/20 0.34
HTR1A P08908 2/20 0.34
HTR2A P28223 2/20 0.34
DRD3 P35462 2/20 0.34
F2 P00734 2/20 0.34
MASP2 O00187 1/20 0.34
CYP2C19 P33261 1/20 0.32
CYP2C9 P11712 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
F10 P00742 1/20 0.32
PLG P00747 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL534419 0.89 SMYD3 (0.39) CYP3A4CYP2D6CYP1A2TSHRMAPK1
SCHEMBL1716130 0.74 SMYD3 (0.52) SMYD3MTNR1AGAAMAPTHTR1A
SCHEMBL516129 0.70 CYP3A4 (0.56) CYP3A4CYP2D6CYP1A2TSHRMAPK1
SCHEMBL516715 0.69 CYP2D6 (0.58) CYP3A4CYP2D6CYP1A2TSHRMAPK1
SCHEMBL23275075 0.69 MTNR1A (0.46) SMYD3MTNR1AGAAMAPTF2
SCHEMBL7954949 0.69 SMYD3 (0.46) SMYD3MTNR1AGAAMAPTHTR1A
SCHEMBL515941 0.67 SMYD3 (0.36) CYP3A4CYP2D6CYP1A2TSHRMAPK1
SCHEMBL515942 0.67 SMYD3 (0.36) CYP3A4CYP2D6CYP1A2TSHRMAPK1
SCHEMBL28119251 0.66 SMYD3 (0.44) SMYD3MTNR1AGAAMAPT
SCHEMBL8568359 0.65 MTNR1A (0.50) TSHRSMYD3MTNR1AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2414323-A1 DERIVATIVES OF AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICAL PRODUCTS Pierre Fabre Médicament (FR) 2012-02-08 EP disclosed
WO-2010112597-A1 DERIVATIVES OF AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICAL PRODUCTS PIERRE FABRE MEDICAMENT (FR) 2010-10-07 WO disclosed