Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NCEH1 | Q6PIU2 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4670678 | 0.85 | NCEH1 (0.38) | RXFP1KMT2ANCEH1TP53SMN1; SMN2 | |
| SCHEMBL6579023 | 0.85 | NCEH1 (0.38) | RXFP1KMT2ANCEH1TP53SMN1; SMN2 | |
| SCHEMBL6582051 | 0.85 | TP53 (0.41) | RXFP1KMT2ANCEH1TP53LMNA | |
| SCHEMBL6583415 | 0.85 | NCEH1 (0.49) | RXFP1KMT2ANCEH1TP53LMNA | |
| SCHEMBL4674130 | 0.84 | ROCK1 (0.41) | RXFP1KMT2ANCEH1STSCYP19A1 | |
| SCHEMBL4670151 | 0.81 | NCEH1 (0.43) | RXFP1KMT2ANCEH1LMNASMN1; SMN2 | |
| SCHEMBL7361821 | 0.81 | RAB9A (0.48) | RXFP1KMT2ANCEH1TP53LMNA | |
| SCHEMBL12370676 | 0.80 | NCEH1 (0.51) | RXFP1KMT2ANCEH1LMNASMN1; SMN2 | |
| SCHEMBL4670146 | 0.80 | NCEH1 (0.40) | RXFP1KMT2ANCEH1SMN1; SMN2HPGD | |
| SCHEMBL4674126 | 0.79 | NCEH1 (0.43) | RXFP1KMT2ANCEH1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163954-B2 | Substituted naphthyl benzothiophene acids | WYETH (US) | 2007-01-16 | — | — | US | disclosed |
| EP-1664015-A1 | SUBSTITUTED NAPHTHYL BENZOTHIOPHENE ACIDS | Wyeth (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005030750-A1 | SUBSTITUTED NAPHTHYL BENZOTHIOPHENE ACIDS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070587-A1 | Substituted naphthyl benzothiophene acids | WYETH (US) | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070587-A1 | Substituted naphthyl benzothiophene acids | TST, GNPAT, NUDT1 | RXFP1 4872/4885KMT2A 2100/4885NCEH1 643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.