Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.46 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3554884 | 0.98 | MAPK1 (0.52) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL5149992 | 0.87 | MAPK1 (0.52) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL899743 | 0.85 | TSHR (0.58) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL357928 | 0.83 | PDK1 (0.55) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL67686 | 0.83 | ALDH1A1 (0.58) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL67536 | 0.81 | MAPK1 (0.53) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL2112011 | 0.81 | MAPK1 (0.53) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL1509585 | 0.81 | MAPK1 (0.53) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL29495064 | 0.81 | MAPK1 (0.53) | MAPK1TSHRVCAM1PDE7APDE7B | |
| SCHEMBL28859046 | 0.81 | MAPK1 (0.53) | MAPK1TSHRVCAM1PDE7APDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160207938-A1 | QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2016-07-21 | — | — | US | disclosed |
| US-9273013-B2 | Quinazoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-01 | — | — | US | disclosed |
| US-20130178624-A1 | QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-11 | — | — | US | disclosed |
| US-8394786-B2 | Quinazoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-03-12 | — | — | US | disclosed |
| CN-102718775-A | Macrocyclic quinazoline derivatives as antiproliferative agents | JANSSEN PHARMACEUTICA NV | 2012-10-10 | — | — | CN | disclosed |
| EP-1633365-B1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2012-02-08 | — | — | EP | disclosed |
| EP-2305687-A1 | Quinazoline derivatives | Janssen Pharmaceutica NV (BE) | 2011-04-06 | — | — | EP | disclosed |
| US-20100105668-A1 | Quinazoline derivatives | FREYNE EDDY JEAN EDGARD | 2010-04-29 | — | — | US | disclosed |
| US-7648975-B2 | Macrocyclic quinazoline derivatives as antiproliferative agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-01-19 | — | — | US | disclosed |
| US-20090192169-A1 | Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators | ASTRAZENECA AB (SE) | 2009-07-30 | — | — | US | disclosed |
| US-20060247237-A1 | Macrocyclic quinazoline derivatives as antiproliferative agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-02 | — | — | US | disclosed |
| CN-1794996-A | Macrocyclic quinazoline derivatives as antiproliferative agents | JANSSEN PHARMACEUTICA NV (BE) | 2006-06-28 | — | — | CN | disclosed |
| EP-1633365-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105765-A1 | MACROCYCLIC QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-12-09 | — | — | WO | disclosed |
| EP-0746558-A1 | PHENYLALKYLAMINO DERIVATIVES OF CONDENSED CARBAPENEMES | GLAXO WELLCOME S.p.A. (IT) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023149-A1 | PHENYLALKYLAMINO DERIVATIVES OF CONDENSED CARBAPENEMES | GLAXO WELLCOME S.P.A. (IT) | 1995-08-31 | — | — | WO | disclosed |
| US-4362666-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1982-12-07 | — | — | US | disclosed |
| US-4316900-A | Piperazinopyrrolobenzodiazepines | CIBA-GEIGY CORPORATION (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0001585-B1 | PIPERAZINO-PYRROLOBENZODIAZEPINES, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1981-07-22 | — | — | EP | disclosed |
| EP-0001585-A1 | Piperazino-pyrrolobenzodiazepines, methods for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1979-05-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178624-A1 | QUINAZOLINE DERIVATIVES | NR1H2, NR1H3, NR3C2 | MAPK1 3902/4885TSHR 496/4885VCAM1 4576/4885 |
| US-20060247237-A1 | Macrocyclic quinazoline derivatives as antiproliferative agents | NR1H3, NR1H2, NCOA3 | MAPK1 3601/4885TSHR 1295/4885VCAM1 4632/4885 |
| US-20090192169-A1 | Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators | GRM1, GRIN1, GRM2 | MAPK1 1819/4885TSHR 467/4885VCAM1 4300/4885 |
| US-20100105668-A1 | Quinazoline derivatives | NR1H2, NR1H3, NR3C2 | MAPK1 4038/4885TSHR 433/4885VCAM1 4630/4885 |
| US-20160207938-A1 | QUINAZOLINE DERIVATIVES | NR1H2, NR1H3, NR3C2 | MAPK1 4018/4885TSHR 362/4885VCAM1 4741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.