Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | USP5 | P45974 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9447463 | 0.90 | PDE4B (0.54) | KMT2APTGS2HPGDRECQLHDAC3 | |
| SCHEMBL7243169 | 0.85 | HPGD (0.53) | KMT2APTGS2HPGDRECQLHDAC3 | |
| SCHEMBL5352346 | 0.84 | HPGD (0.55) | KMT2APTGS2HPGDRECQLHDAC3 | |
| SCHEMBL9447401 | 0.83 | HPGD (0.54) | KMT2APTGS2HPGDRECQLHDAC3 | |
| SCHEMBL9078412 | 0.83 | HPGD (0.54) | KMT2APTGS2HPGDRECQLHDAC3 | |
| SCHEMBL8203459 | 0.81 | HPGD (0.52) | KMT2APTGS2HPGDRECQLHDAC3 | |
| SCHEMBL1474479 | 0.81 | HPGD (0.63) | KMT2APTGS2HPGDRECQLHDAC3 | |
| SCHEMBL11818687 | 0.81 | THRA (0.65) | KMT2AHPGDRECQLHDAC3HDAC4 | |
| SCHEMBL9657514 | 0.81 | HPGD (0.51) | KMT2APTGS2HPGDRECQLHDAC3 | |
| Hydrochloric Acid SCHEMBL11815733 | 0.80 | GSR (0.66) | KMT2AHPGDRECQLHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1328253-C | Fumaric acid ibutilide synthesis method | ZHEJIANG JIUXU PHARMACEUTICAL (CN) | 2007-07-25 | — | — | CN | disclosed |
| US-7232930-B2 | Compounds and methods for preparing methanesulfonamides | PHARMACIA & UPJOHN COMPANY (US) | 2007-06-19 | — | — | US | disclosed |
| US-7232930-B2 | Compounds and methods for preparing methanesulfonamides | PHARMACIA & UPJOHN COMPANY (US) | 2007-06-19 | — | — | US | disclosed |
| US-7232930-B2 | Compounds and methods for preparing methanesulfonamides | PHARMACIA & UPJOHN COMPANY (US) | 2007-06-19 | — | — | US | disclosed |
| CN-1733714-A | Fumaric acid ibutilide synthesis method | ZHEJIANG JIUXU PHARMACEUTICAL (CN) | 2006-02-15 | — | — | CN | disclosed |
| EP-1395549-A1 | COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002098845-A1 | COMPOUNDS AND METHODS FOR PREPARING METHANESULFONAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-12 | — | — | WO | disclosed |
| EP-0802900-B1 | ANTIARRHYTHMIC (S)-ENANTIOMERS OF METHANESULFONAMIDES | UPJOHN CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5874475-A | DO NOT HAVE SIDE EFFECT OF PRODUCING POLYMORPHIC VENTRICULAR TACHYCARDIA | PHARMACIA & UPJOHN COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0802900-A1 | ANTIARRHYTHMIC (S)-ENANTIOMERS OF METHANESULFONAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021643-A1 | ANTIARRHYTHMIC (S)-ENANTIOMERS OF METHANESULFONAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 1996-07-18 | — | — | WO | disclosed |
| US-5405997-A | Stable against rapid metabolism | THE UPJOHN COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | disclosed |
| US-5246946-A | Antiarrhythmia agents and cardiovascular disorders | EISAI CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0304888-B1 | SULFONAMIDOLPHENYL DERIVATES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRYTHMIA CONTAINING SAME | Eisai Co., Ltd. (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-5162347-A | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1992-11-10 | — | — | US | disclosed |
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| US-5082850-A | PIPERIDINE DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRHYTHMIA CONTAINING SAME | EISAI CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| US-4977165-A | Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0304888-A1 | Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same | Eisai Co., Ltd. (JP) | 1989-03-01 | — | — | EP | disclosed |