Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354411 | 0.81 | KMT2A (0.56) | HPGDRECQLHDAC3HDAC4HDAC1 | |
| SCHEMBL9447401 | 0.81 | HPGD (0.54) | HPGDRECQLHDAC3HDAC4HDAC1 | |
| SCHEMBL7243169 | 0.80 | HPGD (0.53) | HPGDRECQLHDAC3HDAC4HDAC1 | |
| SCHEMBL11949250 | 0.80 | SMN1; SMN2 (0.61) | HPGDRECQLMEN1KMT2AKDM4E | |
| SCHEMBL1474479 | 0.79 | HPGD (0.63) | HPGDRECQLHDAC3HDAC4HDAC1 | |
| SCHEMBL5352346 | 0.79 | HPGD (0.55) | HPGDRECQLHDAC3HDAC4HDAC1 | |
| SCHEMBL9078412 | 0.78 | HPGD (0.54) | HPGDRECQLHDAC3HDAC4HDAC1 | |
| SCHEMBL8763454 | 0.78 | GRIN1 (0.65) | HPGDHDAC1HDAC8KDM4ESMN1; SMN2 | |
| SCHEMBL8203484 | 0.76 | LMNA (0.53) | HPGDRECQLMEN1KMT2ACYP2C9 | |
| SCHEMBL11818687 | 0.76 | THRA (0.65) | HPGDRECQLHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802900-B1 | ANTIARRHYTHMIC (S)-ENANTIOMERS OF METHANESULFONAMIDES | UPJOHN CO (US) | 2000-02-16 | — | — | EP | disclosed |
| US-5874475-A | DO NOT HAVE SIDE EFFECT OF PRODUCING POLYMORPHIC VENTRICULAR TACHYCARDIA | PHARMACIA & UPJOHN COMPANY (US) | 1999-02-23 | — | — | US | disclosed |
| EP-0802900-A1 | ANTIARRHYTHMIC (S)-ENANTIOMERS OF METHANESULFONAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021643-A1 | ANTIARRHYTHMIC (S)-ENANTIOMERS OF METHANESULFONAMIDES | PHARMACIA & UPJOHN COMPANY (US) | 1996-07-18 | — | — | WO | disclosed |
| US-5405997-A | Stable against rapid metabolism | THE UPJOHN COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | disclosed |
| EP-0484378-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES. | UPJOHN CO (US) | 1992-05-13 | — | — | EP | disclosed |
| WO-1991001299-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | disclosed |