Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354411 | 0.90 | KMT2A (0.56) | HPGDRECQLPTGS2HDAC3HDAC4 | |
| SCHEMBL9657514 | 0.84 | HPGD (0.51) | HPGDRECQLPTGS2HDAC3HDAC4 | |
| SCHEMBL9078412 | 0.81 | HPGD (0.54) | HPGDRECQLPTGS2HDAC3HDAC4 | |
| SCHEMBL9447401 | 0.81 | HPGD (0.54) | HPGDRECQLPTGS2HDAC3HDAC4 | |
| SCHEMBL7907147 | 0.79 | KDM4E (0.58) | HPGDHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7243169 | 0.79 | HPGD (0.53) | HPGDRECQLPTGS2HDAC3HDAC4 | |
| SCHEMBL1474479 | 0.78 | HPGD (0.63) | HPGDRECQLPTGS2HDAC3HDAC4 | |
| SCHEMBL5352346 | 0.78 | HPGD (0.55) | HPGDRECQLPTGS2HDAC3HDAC4 | |
| SCHEMBL11818687 | 0.78 | THRA (0.65) | HPGDRECQLHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL11815733 | 0.77 | GSR (0.66) | HPGDRECQLHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246946-A | Antiarrhythmia agents and cardiovascular disorders | EISAI CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0304888-B1 | SULFONAMIDOLPHENYL DERIVATES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRYTHMIA CONTAINING SAME | Eisai Co., Ltd. (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-5162347-A | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1992-11-10 | — | — | US | disclosed |
| US-5082850-A | PIPERIDINE DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRHYTHMIA CONTAINING SAME | EISAI CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| US-4977165-A | Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0304888-A1 | Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same | Eisai Co., Ltd. (JP) | 1989-03-01 | — | — | EP | disclosed |