⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL820467 | 1.00 | — | — | |
| SCHEMBL2325910 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL2413368 | 0.97 | — | — | |
| Methylamine SCHEMBL27403434 | 0.97 | CA1 (0.41) | — | |
| SCHEMBL8097160 | 0.85 | MAPT (0.36) | — | |
| SCHEMBL5583603 | 0.82 | ALOX15 (0.34) | — | |
| SCHEMBL15648928 | 0.82 | EPHX1 (0.34) | — | |
| Hydrochloric Acid SCHEMBL15648597 | 0.80 | GNAI3 (0.34) | — | |
| SCHEMBL294878 | 0.78 | — | — | |
| SCHEMBL4107937 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119350173-A | Synthesis method of (S) -2-hydroxybutyramide | 诚达药业股份有限公司 | 2025-01-24 | — | — | CN | claimed |
| CN-119350173-A | Synthesis method of (S) -2-hydroxybutyramide | 诚达药业股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119350173-A | Synthesis method of (S) -2-hydroxybutyramide | 诚达药业股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119350173-A | Synthesis method of (S) -2-hydroxybutyramide | 诚达药业股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-119350213-A | Synthesis method of (R) -4-propyl pyrrolidine-2-ketone | 诚达药业股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| US-20170298027-A1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2017-10-19 | — | — | US | disclosed |
| EP-2753606-B1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA LP (US) | 2017-07-05 | — | — | EP | disclosed |
| US-9656968-B2 | Pyrimidines as sodium channel blockers | PURDUE PHARMA L.P. | 2017-05-23 | — | — | US | disclosed |
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160024022-A1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2016-01-28 | — | — | US | disclosed |
| US-9163008-B2 | Pyrimidines as sodium channel blockers | PURDUE PHARMA, L.P. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20150239866-A1 | TRIAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK CANADA INC. (CA) | 2015-08-27 | — | — | US | disclosed |
| US-20140303139-A1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. | 2014-10-09 | — | — | US | disclosed |
| WO-2013030665-A1 | PYRIMIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2013-03-07 | — | — | WO | disclosed |
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | disclosed |
| WO-2009153720-A1 | NICOTINAMIDE DERIVATIVES | PFIZER LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| US-7279304-B2 | Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-10-09 | — | — | US | disclosed |
| US-20020192773-A1 | Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2002-12-19 | — | — | US | disclosed |
| US-20020042055-A1 | Alteration of hydrolase genes and screening of the resulting libraries for the ability to catalyze specific reactions | MAXYGEN, INC. | 2002-04-11 | — | — | US | disclosed |
| WO-2001046476-A1 | ALTERATION OF HYDROLASE GENES AND SCREENING OF THE RESULTING LIBRARIES FOR THE ABILITY TO CATALYZE SPECIFIC REACTIONS | MAXYGEN, INC. (US) | 2001-06-28 | — | — | WO | disclosed |