Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 7/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083267 | 0.84 | ROCK2 (0.68) | MEN1KMT2ATSHRHTR2BHTR1A | |
| SCHEMBL3977265 | 0.80 | MEN1 (0.64) | MEN1KMT2ATSHRCNR1EPHX2 | |
| SCHEMBL8564336 | 0.80 | MEN1 (0.83) | MEN1KMT2ATSHRCNR1EPHX2 | |
| SCHEMBL7306841 | 0.80 | AKR1C3 (0.62) | MEN1KMT2ATSHRCNR1EPHX2 | |
| SCHEMBL15916783 | 0.79 | EPHX2 (0.50) | TSHREPHX2HTR6MAPT | |
| SCHEMBL14919477 | 0.79 | MEN1 (0.68) | MEN1KMT2ATSHRCNR1EPHX2 | |
| SCHEMBL17303497 | 0.79 | EPHX2 (0.50) | TSHREPHX2 | |
| SCHEMBL15915662 | 0.79 | EPHX2 (0.50) | TSHREPHX2HTR6MAPT | |
| SCHEMBL15915660 | 0.79 | EPHX2 (0.50) | TSHREPHX2HTR6MAPT | |
| SCHEMBL5245792 | 0.79 | TSHR (0.62) | TSHRMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6734182-B2 | SLEEP DISORDERS; EATING DISORDERS; SEXUAL DISORDERS; HYPOTENSIVE AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-05-11 | — | — | US | disclosed |
| US-20030013714-A1 | Aryl sulfonamides and sulfamide derivatives and uses thereof | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-01-16 | — | — | US | disclosed |
| US-6391877-B1 | EATING DISORDERS; SEXUAL DISORDERS; ANTIDEPRESSANTS; ANTIEPILEPTIC AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-6211241-B1 | ANTIDEPRESSANTS, SLEEP AND EATING DISORDERS AND ANTIEPILEPTIC AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-04-03 | — | — | US | disclosed |
| WO-1997019682-A1 | ARYL SULFONAMIDE AND SULFAMIDE DERIVATIVES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013714-A1 | Aryl sulfonamides and sulfamide derivatives and uses thereof | NPY5R, SSTR5, NPY2R | MEN1 3649/4885KMT2A 1117/4885TSHR 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.