Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.39 |
| ▸ | FEN1 | P39748 | 5/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | DDO | Q99489 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362169 | 0.84 | KDR (0.77) | KDRALOX5APFEN1CHEK1TDP1 | |
| SCHEMBL5355082 | 0.78 | KDR (0.73) | KDRALOX5APFEN1CHEK1 | |
| SCHEMBL5355698 | 0.70 | KDR (1.00) | KDRCHEK1 | |
| SCHEMBL5358982 | 0.69 | KDR (0.89) | KDRCHEK1 | |
| SCHEMBL5362580 | 0.67 | KDR (0.70) | KDRALOX5APFEN1CHEK1TDP1 | |
| SCHEMBL5359215 | 0.64 | KDR (0.67) | KDRALOX5APFEN1CHEK1TDP1 | |
| SCHEMBL15942385 | 0.62 | DAO (0.53) | KDRCHEK1DAODDO | |
| SCHEMBL5355363 | 0.62 | KDR (0.85) | KDRCHEK1 | |
| SCHEMBL5367711 | 0.60 | KDR (0.70) | KDRCHEK1 | |
| SCHEMBL6795564 | 0.60 | MEN1 (0.60) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |
| US-7169788-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-01-30 | — | — | US | disclosed |