SCHEMBL535514

SCHEMBL535514

Cc1cc(Cl)ncc1NC(=O)OC(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ATR Q13535 1/20 0.43
BRD9 Q9H8M2 1/20 0.39
P2RX3 P56373 2/20 0.39
AAK1 Q2M2I8 2/20 0.39
LCK P06239 4/20 0.39
MAPKAPK2 P49137 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA9 Q16790 1/20 0.39
METAP1 P53582 1/20 0.38
TRPA1 O75762 1/20 0.38
BRD4 O60885 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16879643 0.86 ATR (0.44) ATRBRD9P2RX3AAK1LCK
SCHEMBL17336445 0.85 AAK1 (0.44) ATRBRD9AAK1LCKCA12
SCHEMBL29948300 0.84 CYP17A1 (0.46) ATRP2RX3AAK1MAPKAPK2METAP1
SCHEMBL18369794 0.84 ATR (0.42) ATRBRD9P2RX3AAK1MAPKAPK2
SCHEMBL1970778 0.84 CYP17A1 (0.46) ATRP2RX3AAK1MAPKAPK2METAP1
SCHEMBL17336530 0.84 AAK1 (0.42) ATRBRD9P2RX3AAK1LCK
SCHEMBL29364468 0.84 ATR (0.42) ATRBRD9P2RX3AAK1MAPKAPK2
SCHEMBL1581324 0.84 ATR (0.42) ATRBRD9P2RX3AAK1MAPKAPK2
SCHEMBL12584018 0.84 MAPKAPK2 (0.43) ATRP2RX3AAK1MAPKAPK2METAP1
SCHEMBL21262226 0.83 ATR (0.44) ATRBRD9P2RX3AAK1LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022076975-A1 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES ENLIVEN THERAPEUTICS, INC. (US) 2022-04-14 WO disclosed
EP-3689860-A1 SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2020-08-05 EP disclosed
US-10011568-B2 Cyclohexyl pyridine derivative KISSEI PHARMACEUTICAL CO., LTD. (JP) 2018-07-03 US disclosed
US-20170298024-A1 CYCLOHEXYL PYRIDINE DERIVATIVE KISSEI PHARMACEUTICAL CO., LTD. (JP) 2017-10-19 US disclosed
US-9708266-B2 Cyclohexyl pyridine derivative KISSEI PHARMACEUTICAL CO., LTD. (JP) 2017-07-18 US disclosed
US-20170057920-A1 CYCLOHEXYL PYRIDINE DERIVATIVE KISSEI PHARMACEUTICAL CO., LTD. (JP) 2017-03-02 US disclosed
US-20160289206-A1 CARBOXYMETHYL PIPERIDINE DERIVATIVE KISSEI PHARMACEUTICAL CO., LTD. (JP) 2016-10-06 US disclosed
US-8426450-B1 Substituted 4-phenyl pyridines having anti-emetic effect HELSINN HEALTHCARE SA (CH) 2013-04-23 US disclosed
US-8404708-B2 Dual NK1/NK3 receptor antagonists HOFFMANN-LA ROCHE INC. (US) 2013-03-26 US disclosed
US-8247431-B2 Heterocyclic hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-21 US disclosed
US-8247431-B2 Heterocyclic hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-21 US disclosed
EP-2144898-B1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2012-02-08 EP disclosed
EP-2144898-B1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2012-02-08 EP disclosed
US-20110178055-A1 DUAL NK1/NK3 RECEPTOR ANTAGONISTS HOFFMANN TORSTEN 2011-07-21 US disclosed
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
EP-2144898-A2 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2010-01-20 EP disclosed
WO-2008130021-A2 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-10-30 WO disclosed
WO-2008130021-A2 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-10-30 WO disclosed
EP-1643998-B1 DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA HOFFMANN LA ROCHE (CH) 2007-08-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110178055-A1 DUAL NK1/NK3 RECEPTOR ANTAGONISTS TACR2, TAC3, TACR1 ATR 4649/4885BRD9 3289/4885P2RX3 220/4885
US-20170298024-A1 CYCLOHEXYL PYRIDINE DERIVATIVE CYP3A43, CYP3A5, CYP3A4 ATR 2723/4885BRD9 3068/4885P2RX3 79/4885
US-10011568-B2 Cyclohexyl pyridine derivative CYP3A43, CYP3A5, CYP3A4 ATR 2723/4885BRD9 3068/4885P2RX3 79/4885
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, CAT, DNPH1 ATR 3515/4885BRD9 1859/4885P2RX3 1265/4885
US-20160289206-A1 CARBOXYMETHYL PIPERIDINE DERIVATIVE TACR1, CYP3A5, CNR1 ATR 2414/4885BRD9 1517/4885P2RX3 80/4885
US-20170057920-A1 CYCLOHEXYL PYRIDINE DERIVATIVE CYP3A43, CYP3A5, CYP3A4 ATR 2742/4885BRD9 3058/4885P2RX3 82/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.