Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28251696 | 0.86 | LMNA (0.50) | LMNAMAPK1ALDH1A1HTTTSHR | |
| SCHEMBL28251680 | 0.81 | LMNA (0.49) | LMNAMAPK1ALDH1A1HTTTSHR | |
| SCHEMBL28252178 | 0.81 | LMNA (0.49) | LMNAMAPK1ALDH1A1HTTTSHR | |
| SCHEMBL28251690 | 0.81 | LMNA (0.49) | LMNAMAPK1ALDH1A1HTTTSHR | |
| SCHEMBL6660171 | 0.81 | CDK1 (0.63) | LMNAMAPK1ALDH1A1HTTTSHR | |
| SCHEMBL31061395 | 0.80 | EGFR (0.59) | LMNAMAPK1ALDH1A1HTTTSHR | |
| SCHEMBL4121599 | 0.78 | SRC (0.67) | LMNAMAPK1ALDH1A1HTTTSHR | |
| SCHEMBL16393083 | 0.76 | BRD4 (0.47) | MAPK1NPC1RAB9AHDAC1HDAC2 | |
| SCHEMBL23771392 | 0.75 | YTHDC1 (0.66) | — | |
| SCHEMBL15518357 | 0.73 | NPC1 (0.46) | LMNAMAPK1ALDH1A1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | claimed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | claimed |
| JP-2007231023-A | PURINE DERIVATIVE AND METHOD FOR PRODUCING THE SAME | NOVARTIS AG | 2007-09-13 | — | — | JP | disclosed |