Toluene

Toluene

SCHEMBL53563

Cc1ccccc1.O=S(=O)(Cl)Cl

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 2/20 0.65
ACHE P22303 2/20 0.65
LMNA P02545 2/20 0.65
TSHR P16473 1/20 0.65
ALDH1A1 P00352 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
HSD17B10 Q99714 1/20 0.50
CA12 O43570 4/20 0.45
CA9 Q16790 4/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
GAA P10253 4/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
HTT P42858 1/20 0.43
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
HPGD P15428 2/20 0.42
KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL2874261 1.00 ALOX12 (0.65) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL14976964 1.00 ALOX12 (0.65) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL28783164 1.00 ALOX12 (0.65) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL27303187 0.97 ALOX12 (0.61) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL27554213 0.92 ALOX12 (0.61) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL27594905 0.89 LMNA (0.58) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL2780838 0.89 ALOX12 (0.58) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL1148280 0.89 LMNA (0.58) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL28369963 0.88 LMNA (0.50) ALOX12ACHELMNATSHRALDH1A1
Toluene SCHEMBL27539266 0.88 ALOX12 (0.50) ALOX12ACHELMNATSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4649 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260049059-A1 A PROCESS FOR PREPARATION OF CABOZANTINIB OR TIVOZANIB SYNTHON BV (NL) 2026-02-19 US claimed
EP-4622961-A1 A PROCESS FOR PREPARATION OF CABOZANTINIB OR TIVOZANIB Synthon B.V. (NL) 2025-10-01 EP claimed
US-20250215003-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF RUXOLITINIB GRANULES INDIA LIMITED (IN) 2025-07-03 US claimed
CN-120157730-A Synthesis method of 7-dehydrocholesterol and derivatives thereof 氘益有氘(天津)药业有限公司 2025-06-17 CN claimed
CN-119350563-B Polymer capable of being assembled with protein and hydrophobic small molecule medicine and preparation method thereof 至微(深圳)医学科技有限公司 2025-04-04 CN claimed
US-12226405-B2 Compounds and compositions for inhibiting the activity of HIF2-alpha and their methods of use NOVARTIS AG (CH) 2025-02-18 US claimed
CN-119350563-A Polymer capable of being assembled with protein and hydrophobic small molecule medicine and preparation method thereof 至微(深圳)医学科技有限公司 2025-01-24 CN claimed
CN-119307111-A Biological nano waterproof fiber material and preparation method thereof 中极木雨新材料科技(苏州)有限公司 2025-01-14 CN claimed
CN-119241732-A Preparation method of quaternized lignocellulose nanofibrils and hydrogel drug carrier 广西民族大学 2025-01-03 CN claimed
EP-4463460-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF RUXOLITINIB Granules India Limited (IN) 2024-11-20 EP claimed
CN-1051362-A The new omega-phenylamino alkanoic acids that on virtue nuclear, replaces and the preparation method of salt thereof by 19-norsteroid deutero-group ROUSSEL UCLAF (FR) 1991-05-15 CN claimed
CN-1048695-A The normal temperature rapid concretion technology for making Mg-C brick SPECIAL REFRACTORY MATERIALS G (CN) 1991-01-23 CN claimed
CN-1047295-A The preparation of diazabicyclo intermediate PFIZER (US) 1990-11-28 CN claimed
EP-0368154-A1 Polyether bis-phosphonic acid compounds W.R. Grace & Co.-Conn. (US) 1990-05-16 EP claimed
EP-0322494-A1 A method for the treatment of dinitroanilines to reduce their nitrosamine content and/or to stabilise them against the formation of nitrosamines FINCHIMICA S.p.A. (IT) 1989-07-05 EP claimed
US-4739116-A Preparation of arylsulfonamides AKZO AMERICA INC. (US) 1988-04-19 US claimed
CN-87103193-A Steroid compounds containing a spiro ring in position 17, process and intermediates for their production, their use as medicaments and pharmaceutical compositions containing them 1988-01-13 CN claimed
US-4713489-A Preparation of N-substituted arylsulfonamides AKZO AMERICA INC. (US) 1987-12-15 US claimed
US-4710562-A Stabilizing polyaryletherketones AMOCO CORPORATION (US) 1987-12-01 US claimed
CN-86100254-A The method for preparing tertiary amine compounds 1986-10-08 CN claimed