SCHEMBL5358012

SCHEMBL5358012

CCCCCCCCCCCCCCCC(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.58
ENPP1 P22413 3/20 0.57
P2RY1 P47900 1/20 0.57
AHCY P23526 1/20 0.50
EHMT1 Q9H9B1 1/20 0.50
PRKACA P17612 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6534229 1.00 POLB (0.58) POLBENPP1P2RY1AHCYEHMT1
SCHEMBL5369306 0.96 POLB (0.59) POLBENPP1P2RY1AHCYEHMT1
SCHEMBL5359628 0.90 HIF1A (0.48) POLBENPP1P2RY1
SCHEMBL22875428 0.90 AHCY (0.47) POLBENPP1P2RY1AHCYEHMT1
SCHEMBL2691352 0.88 POLB (0.62) POLBENPP1P2RY1AHCYPRKACA
SCHEMBL8058699 0.86 POLB (0.64) POLBENPP1P2RY1AHCY
SCHEMBL1889395 0.86 POLB (0.64) POLBENPP1P2RY1AHCY
SCHEMBL8623380 0.85 POLB (0.65) POLBENPP1P2RY1AHCY
SCHEMBL3259692 0.85 POLB (0.65) POLBENPP1P2RY1AHCY
SCHEMBL7133529 0.85 POLB (0.59) POLBENPP1P2RY1AHCYPRKACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7169765-B1 Acyl deoxyribonucleoside derivatives and uses thereof WELLSTAT THERAPEUTICS CORPORATION (US) 2007-01-30 US disclosed
EP-0712629-B1 Acyl deoxyribonucleoside derivatives and uses thereof WELLSTAT THERAPEUTICS CORP (US) 2003-06-18 EP disclosed
US-6348451-B1 WOUND HEALING AGENTS FOR ANIMALS PRO-NEURON, INC. 2002-02-19 US disclosed
US-6306834-B1 METHODS OF TREATING OR PREVENTING RADIATION, MUTAGEN AND SUNLIGHT-INDUCED BIOLOGICAL DAMAGE, METHODS FOR IMPROVING WOUND HEALING AND TISSUE REPAIR, COMPRISING ADMINISTERING THE COMPOSITIONS OF THE PRESENT INVENTION TO AN ANIMAL. PRO-NEURON, INC. 2001-10-23 US disclosed
US-6297222-B1 TREATING OR PREVENTING RADIATION, MUTAGEN AND SUNLIGHT-INDUCED BIOLOGICAL DAMAGE, AND METHODS FOR IMPROVING WOUND HEALING AND TISSUE REPAIR PRO-NEURON, INC. 2001-10-02 US disclosed
EP-0355131-B1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO NEURON INC (US) 1996-09-04 EP disclosed
EP-0712629-A1 Acyl deoxyribonucleoside derivatives and uses thereof PRO-NEURON, INC. (US) 1996-05-22 EP disclosed
EP-0355131-A1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO-NEURON, INC. (US) 1990-02-28 EP disclosed