Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 6/20 | 0.37 |
| ▸ | TYMP | P19971 | 2/20 | 0.36 |
| ▸ | TK2 | O00142 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928564 | 0.90 | TK1 (0.38) | TK1TYMPTK2KMT2AMAPK1 | |
| SCHEMBL6924148 | 0.90 | TK1 (0.38) | TK1TYMPTK2KMT2AMAPK1 | |
| SCHEMBL6924149 | 0.85 | TK1 (0.39) | TK1TYMPTK2KMT2AHPGD | |
| SCHEMBL6931042 | 0.85 | TK1 (0.39) | TK1TYMPTK2KMT2AHPGD | |
| SCHEMBL5358378 | 0.83 | TK1 (0.36) | TK1TYMPTK2KMT2AMAPK1 | |
| SCHEMBL8135550 | 0.83 | TK1 (0.37) | TK1TYMPTK2KMT2AHPGD | |
| SCHEMBL8150170 | 0.80 | TK1 (0.41) | TK1TK2KMT2AMAPK1HPGD | |
| SCHEMBL5349908 | 0.80 | TK1 (0.39) | TK1TK2KMT2AHPGD | |
| SCHEMBL5366400 | 0.79 | KMT2A (0.40) | TK1TYMPKMT2AMAPK1 | |
| SCHEMBL6468180 | 0.77 | TK1 (0.37) | TK1TYMPKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223833-B1 | Peptide nucleic acid conjugates | ISIS PHARMACEUTICALS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-0804456-B1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-0804456-A4 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0804456-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011205-A9 | PEPTIDE NUCLEIC ACID CONJUGATES | — | 1996-05-30 | — | — | WO | disclosed |
| WO-1996011205-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1996-04-18 | — | — | WO | disclosed |