Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 4/20 | 0.36 |
| ▸ | TYMP | P19971 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TK2 | O00142 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924145 | 0.89 | TK1 (0.37) | TK1TYMPSMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL6928560 | 0.89 | TK1 (0.37) | TK1TYMPSMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL6924142 | 0.84 | TK1 (0.38) | TK1TYMPKMT2ATK2 | |
| SCHEMBL6931032 | 0.84 | TK1 (0.38) | TK1TYMPKMT2ATK2 | |
| SCHEMBL6513732 | 0.84 | TK1 (0.38) | TK1TYMPKMT2ATK2 | |
| SCHEMBL5358371 | 0.83 | TK1 (0.37) | TK1TYMPKMT2AMAPK1TK2 | |
| SCHEMBL6513527 | 0.79 | L3MBTL1 (0.42) | TK1KMT2AMAPK1 | |
| SCHEMBL5175003 | 0.79 | KMT2A (0.40) | TK1SMN1; SMN2KMT2ALMNATK2 | |
| SCHEMBL5158820 | 0.78 | TK1 (0.37) | TK1TK2 | |
| SCHEMBL8642052 | 0.78 | TK1 (0.39) | TK1KMT2AMAPK1TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223833-B1 | Peptide nucleic acid conjugates | ISIS PHARMACEUTICALS, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-0804456-B1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 2002-08-21 | — | — | EP | disclosed |
| EP-0804456-A4 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS INC (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0804456-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011205-A9 | PEPTIDE NUCLEIC ACID CONJUGATES | — | 1996-05-30 | — | — | WO | disclosed |
| WO-1996011205-A1 | PEPTIDE NUCLEIC ACID CONJUGATES | ISIS PHARMACEUTICALS, INC. (US) | 1996-04-18 | — | — | WO | disclosed |