⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682461 | 0.74 | — | — | |
| SCHEMBL5772420 | 0.73 | ALDH1A1 (0.34) | — | |
| SCHEMBL27965804 | 0.72 | — | — | |
| SCHEMBL3940349 | 0.69 | DAO (0.31) | — | |
| SCHEMBL1453412 | 0.68 | ALDH1A1 (0.31) | — | |
| SCHEMBL22367347 | 0.68 | KDM4E (0.35) | — | |
| SCHEMBL1164353 | 0.67 | — | — | |
| SCHEMBL1452251 | 0.67 | NOS2 (0.33) | — | |
| SCHEMBL892277 | 0.66 | HTT (0.41) | — | |
| SCHEMBL2481986 | 0.65 | HPGD (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7163946-B2 | 5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2007-01-16 | — | — | US | disclosed |
| EP-1554283-A1 | 5-SUBSTITUTED 7,9-DIFLUORO-5 I H /I -CHROMENO (3,4-F) QUINOLINE COMPOUNDS AS SELECTIVE PROGESTERONE RECEPTOR MODULATORS | LIGAND PHARMACEUTICALS, INC. (US) | 2005-07-20 | — | — | EP | disclosed |
| US-20040152717-A1 | 5-Substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds | LIGAND PHARMACEUTICALS INC. | 2004-08-05 | — | — | US | disclosed |
| WO-2004033461-A1 | 5-SUBSTITUTED 7,9-DIFLUORO-5H-CHROMENO[3,4-f]QUINOLINE COMPOUNDS AS SELECTIVE PROGESTERONE RECEPTOR MODULATORS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2004-04-22 | — | — | WO | disclosed |