SCHEMBL5360128

SCHEMBL5360128

C=C(CO[Si](C)(C)C)C(N)=O

nearest known ligand 0.38

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1570547 0.78 TET2 (0.37)
SCHEMBL1000321 0.75
SCHEMBL3980516 0.74 TDP1 (0.38) TDP1
SCHEMBL28569328 0.74
SCHEMBL1011995 0.71
SCHEMBL7776382 0.71 TDP1 (0.43) TDP1
SCHEMBL6897119 0.71
SCHEMBL5088974 0.70 TDP1 (0.41) TDP1
Ether SCHEMBL8665518 0.70 ALOX15 (0.37) TDP1
SCHEMBL28114473 0.70 TDP1 (0.36) TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39635-E1 Polymerizing a hydrophobic siloxane prepolymer and a silylated hydrophobic monomer and hydrolyzing the resulting polymer polymerization is carried out by using one of heat or ultraviolet light VANDERLAAN DOUGLAS G 2007-05-15 US claimed
EP-0990668-B1 Optically transparent hydrogels and processes for their production JOHNSON & JOHNSON VISION PROD (US) 2002-11-27 EP claimed
EP-0990668-A1 Optically transparent hydrogels and processes for their production JOHNSON & JOHNSON VISION PRODUCTS, INC. (US) 2000-04-05 EP claimed
US-6031059-A POLYMERIZING A HYDROPHOBIC SILOXANE PREPOPLYMER AND A SILYLATED HYDROPHILIC MONOMER AND HYDROLYZING THE RESULTING POLYMER WHEREIN POLYMERIZING IS CARRIED OUT BY USING ONE OF HEAT POLYMERIZATION, ULTRAVIOLET LIGHT JOHNSON & JOHNSON VISION PRODUCTS, INC. (US) 2000-02-29 US claimed
US-RE39635-E1 Polymerizing a hydrophobic siloxane prepolymer and a silylated hydrophobic monomer and hydrolyzing the resulting polymer polymerization is carried out by using one of heat or ultraviolet light VANDERLAAN DOUGLAS G 2007-05-15 US disclosed
EP-0990668-B1 Optically transparent hydrogels and processes for their production JOHNSON & JOHNSON VISION PROD (US) 2002-11-27 EP disclosed
EP-0990668-A1 Optically transparent hydrogels and processes for their production JOHNSON & JOHNSON VISION PRODUCTS, INC. (US) 2000-04-05 EP disclosed
US-6031059-A POLYMERIZING A HYDROPHOBIC SILOXANE PREPOPLYMER AND A SILYLATED HYDROPHILIC MONOMER AND HYDROLYZING THE RESULTING POLYMER WHEREIN POLYMERIZING IS CARRIED OUT BY USING ONE OF HEAT POLYMERIZATION, ULTRAVIOLET LIGHT JOHNSON & JOHNSON VISION PRODUCTS, INC. (US) 2000-02-29 US disclosed