Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323167 | 0.84 | PKM (0.64) | KMT2ANPSR1L3MBTL1GAAHSD11B1 | |
| SCHEMBL5326546 | 0.84 | MAPT (0.57) | KMT2AMAPTL3MBTL1GAAHSD11B1 | |
| SCHEMBL16707660 | 0.84 | MEN1 (0.55) | KMT2AL3MBTL1GAAHSD11B1PKM | |
| SCHEMBL5352439 | 0.82 | MCOLN3 (0.50) | KMT2AL3MBTL1HSD11B1PKMNAMPT | |
| SCHEMBL5327466 | 0.81 | PKM (0.59) | KMT2AMAPTL3MBTL1GAAHSD11B1 | |
| SCHEMBL5357244 | 0.81 | KDM4E (0.66) | KMT2AL3MBTL1HSD11B1PKMGBA1 | |
| SCHEMBL13271173 | 0.80 | USP2 (0.62) | KMT2AMAPTNPSR1L3MBTL1GAA | |
| SCHEMBL5351313 | 0.80 | ALDH1A1 (0.61) | KMT2AMAPTL3MBTL1GBA1NAMPT | |
| SCHEMBL5351297 | 0.79 | KDM4E (0.59) | MAPTL3MBTL1GAAPKMGBA1 | |
| SCHEMBL5323174 | 0.78 | MCOLN3 (0.60) | KMT2AHSD11B1PKMPKLRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | claimed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |