Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323167 | 0.87 | PKM (0.64) | KMT2ALMNAALDH1A1MEN1HTT | |
| SCHEMBL16707660 | 0.87 | MEN1 (0.55) | KMT2ALMNAALDH1A1MEN1HTT | |
| SCHEMBL5357244 | 0.86 | KDM4E (0.66) | KMT2ALMNAALDH1A1MAPK1PKM | |
| SCHEMBL5352439 | 0.85 | MCOLN3 (0.50) | KMT2ALMNAALDH1A1MEN1HTT | |
| SCHEMBL5360178 | 0.84 | KMT2A (0.57) | MAPTKMT2AALDH1A1MEN1HTT | |
| SCHEMBL5327466 | 0.84 | PKM (0.59) | MAPTKMT2ALMNAALDH1A1HTT | |
| SCHEMBL16707647 | 0.83 | FKBP1A (0.58) | MAPTKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL5351313 | 0.83 | ALDH1A1 (0.61) | MAPTKMT2ALMNAALDH1A1TSHR | |
| SCHEMBL14386681 | 0.81 | GCK (0.56) | MAPTLMNAALDH1A1PKML3MBTL1 | |
| SCHEMBL5323174 | 0.81 | MCOLN3 (0.60) | KMT2ALMNAMEN1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | claimed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007122411-A1 | DIAZEPAN-1-YL-SULFONYL DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | ASTRAZENECA AB (SE) | 2007-11-01 | — | — | WO | disclosed |