SCHEMBL5360459

SCHEMBL5360459

COC(=O)NC(=O)C1CC2C=CC1C2

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.61
LMNA P02545 1/20 0.61
THRB P10828 1/20 0.44
ALDH1A1 P00352 4/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 2/20 0.39
POLB P06746 2/20 0.39
SMN1; SMN2 Q16637 3/20 0.37
RAB9A P51151 2/20 0.37
NPC1 O15118 1/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
PKM P14618 1/20 0.35
APEX1 P27695 1/20 0.34
RECQL P46063 1/20 0.34
BLM P54132 1/20 0.34
ESR2 Q92731 1/20 0.34
HSD17B10 Q99714 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5347101 0.84 KDM4E (0.54) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL5366429 0.81 KDM4E (0.62) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL5360974 0.78 KDM4E (0.69) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL13714939 0.78 KDM4E (0.58) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL29483886 0.78 KDM4E (0.58) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL23016645 0.78 KDM4E (0.58) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL11509527 0.78 KDM4E (0.58) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL24908346 0.78 KDM4E (0.58) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL19220253 0.78 KDM4E (0.58) KDM4ELMNATHRBALDH1A1HPGD
SCHEMBL75461 0.78 KDM4E (0.58) KDM4ELMNATHRBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7202016-B2 Radiation-sensitive resin composition JSR CORPORATION (JP) 2007-04-10 US disclosed
US-20050214680-A1 Radiation-sensitive resin composition MIYAJI MASAAKI 2005-09-29 US disclosed
US-6933094-B2 Radiation-sensitive resin composition JSR CORPORATION (JP) 2005-08-23 US disclosed
US-20020058201-A1 Radiation-sensitive resin composition JSR CORPORATION (JP) 2002-05-16 US disclosed
EP-1193558-A2 Radiation-sensitive resin composition JSR Corporation (JP) 2002-04-03 EP disclosed