Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.63 |
| ▸ | CA2 | P00918 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | MIF | P14174 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 5/20 | 0.58 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | ALPG | P10696 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11517562 | 0.86 | CA1 (0.71) | CA1CA2RAB9ANPC1ALDH1A1 | |
| SCHEMBL5695334 | 0.83 | RAB9A (0.71) | CA1CA2RAB9ANPC1ALDH1A1 | |
| SCHEMBL7556866 | 0.83 | ALDH1A1 (0.79) | CA1CA2RAB9ANPC1ALDH1A1 | |
| SCHEMBL687614 | 0.83 | ALDH1A1 (0.69) | CA1CA2RAB9ANPC1ALDH1A1 | |
| SCHEMBL27776624 | 0.83 | RAB9A (0.76) | RAB9ANPC1ALDH1A1POLBMEN1 | |
| SCHEMBL16918559 | 0.81 | RAB9A (0.86) | CA1CA2RAB9ANPC1ALDH1A1 | |
| SCHEMBL29971986 | 0.81 | RAB9A (0.86) | CA1CA2RAB9ANPC1ALDH1A1 | |
| SCHEMBL456985 | 0.79 | ALDH1A1 (0.70) | CA1CA2RAB9ANPC1ALDH1A1 | |
| SCHEMBL5210059 | 0.79 | KMT2A (0.62) | CA1CA2RAB9ANPC1MEN1 | |
| SCHEMBL23932088 | 0.78 | KMT2A (0.66) | CA2RAB9ANPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241783-B2 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1349613-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2005-09-21 | — | — | EP | disclosed |
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| US-20040058990-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION | 2004-03-25 | — | — | US | disclosed |
| EP-1349613-A2 | THROMBOPOIETIN MIMETICS | SmithKline Beecham Corporation (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
| WO-2002049413-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058990-A1 | Thrombopoietin mimetics | MPL, THPO, TEK | CA1 4305/4885CA2 4643/4885RAB9A 3652/4885 |
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | CA1 4519/4885CA2 3937/4885RAB9A 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.