Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868782 | 0.98 | ALDH1A1 (0.53) | ALDH1A1CYP2D6ATMPOLBPDE3B | |
| SCHEMBL23440396 | 0.84 | PRKDC (0.48) | ALDH1A1CYP2D6ATMLTA4HNPSR1 | |
| Ammonia Solution, Strong SCHEMBL5381714 | 0.80 | MPO (0.35) | LMNA | |
| SCHEMBL28611579 | 0.79 | ALDH1A1 (0.48) | ALDH1A1CYP2D6ATMPOLBPDE3B | |
| SCHEMBL10306518 | 0.78 | PRKDC (0.50) | ALDH1A1CYP2D6ATMPOLBLTA4H | |
| SCHEMBL28585742 | 0.77 | ALDH1A1 (0.64) | ALDH1A1CYP2D6ATMPOLBPDE3B | |
| SCHEMBL19785487 | 0.77 | CSF1R (0.50) | ALDH1A1CYP2D6ATMNPC1RAB9A | |
| SCHEMBL29361274 | 0.77 | CSF1R (0.50) | ALDH1A1CYP2D6ATMNPC1RAB9A | |
| SCHEMBL1396856 | 0.77 | ALDH1A1 (0.48) | ALDH1A1CYP2D6ATMPOLBPDE3B | |
| SCHEMBL26131691 | 0.76 | ALDH1A1 (0.54) | ALDH1A1CYP2D6ATMPOLBPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250417-B2 | Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors | SUGEN INC. (US) | 2007-07-31 | — | — | US | disclosed |
| EP-1643836-A4 | ARYLMETHYL TRIAZOLO AND IMIDAZOPYRAZINES AS C-MET INHIBITORS | SUGEN INC (US) | 2006-12-06 | — | — | EP | disclosed |
| EP-1643836-A1 | ARYLMETHYL TRIAZOLO AND IMIDAZOPYRAZINES AS C-MET INHIBITORS | Sugen, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| US-20050107391-A1 | Arylmethyl triazolo-and imidazopyrazines as c-Met inhibitors | SUGEN, INC. | 2005-05-19 | — | — | US | disclosed |
| WO-2005004607-A1 | ARYLMETHYL TRIAZOLO AND IMIDAZOPYRAZINES AS C-MET INHIBITORS | SUGEN, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107391-A1 | Arylmethyl triazolo-and imidazopyrazines as c-Met inhibitors | MET, RET, IGF1R | ALDH1A1 725/4885CYP2D6 782/4885ATM 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.