Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | CHRNA10 | Q9GZZ6 | 11/20 | 0.41 |
| ▸ | CHRNA9 | Q9UGM1 | 11/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.41 |
| ▸ | S100B | P04271 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.34 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746050 | 0.99 | GAA (0.50) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| Hydrochloric Acid SCHEMBL5345795 | 0.95 | GAA (0.53) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| Hydrochloric Acid SCHEMBL5397681 | 0.94 | GAA (0.49) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| SCHEMBL6746574 | 0.94 | GAA (0.55) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| SCHEMBL6748617 | 0.93 | GAA (0.50) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| Hydrochloric Acid SCHEMBL5346509 | 0.89 | GAA (0.54) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| SCHEMBL14559154 | 0.88 | GAA (0.55) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| Hydrochloric Acid SCHEMBL5352676 | 0.84 | CHRNA10 (0.48) | GAARAD52CHRNA10CHRNA9CHRNA7 | |
| Hydrochloric Acid SCHEMBL5403739 | 0.83 | GAA (0.48) | GAARAD52CHRNA10CHRNA9S100B | |
| SCHEMBL6742112 | 0.83 | CHRNA10 (0.49) | GAARAD52CHRNA10CHRNA9CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186277-B2 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | L'OREAL SA (FR) | 2007-03-06 | — | — | US | claimed |
| US-20040237216-A1 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | L'OREAL S.A. (FR) | 2004-12-02 | — | — | US | claimed |
| US-7186277-B2 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | L'OREAL SA (FR) | 2007-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040237216-A1 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | KRT18, CDC73, DSP | GAA 4807/4885RAD52 651/4885CHRNA10 898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.