Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5303247 | 0.83 | CYP2A6 (0.37) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL5299686 | 0.76 | ADORA3 (0.46) | ADORA2AADORA1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27819283 | 0.72 | CYP2A6 (0.47) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL28239901 | 0.69 | CYP2A6 (0.47) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL243297 | 0.66 | PLAU (0.50) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL30307857 | 0.66 | PLAU (0.55) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL2792111 | 0.66 | PLAU (0.55) | PLAUF12NCF1NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL5214220 | 0.65 | PLAU (0.53) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL23886136 | 0.64 | PLAU (0.47) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL2307025 | 0.64 | PLAU (0.52) | PLAUF12NCF1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007012724-A1 | 1,2,4-THIADIAZOLE DERIVATIVES ANTIFUNGAL COMPOUNDS, COMPOSITIONS CONTAINING SAID COMPOUNDS AND THE USE THEREOF | CYTOMICS SYSTEMS (FR) | 2007-02-01 | — | — | WO | claimed |