Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | SLC34A1 | Q06495 | 5/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378734 | 0.77 | TDP2 (0.48) | TDP2SLC34A1CACNA2D1SCN5AMAPT | |
| SCHEMBL20074707 | 0.69 | SLC34A1 (0.47) | TDP2SLC34A1PDE2ASCN5AMAPT | |
| SCHEMBL17290717 | 0.69 | SLC34A1 (0.47) | TDP2SLC34A1CACNA2D1SCN5AMAPT | |
| SCHEMBL20074733 | 0.69 | SLC34A1 (0.47) | TDP2SLC34A1CACNA2D1SCN5AMAPT | |
| SCHEMBL130643 | 0.68 | NUDT14 (0.68) | ABL1KDM4EALDH1A1 | |
| SCHEMBL25286772 | 0.68 | TEAD1 (0.43) | TDP2SLC34A1PDE2ACACNA2D1SCN5A | |
| SCHEMBL14960652 | 0.67 | KDM4E (0.46) | TDP2ABL1BCRCACNA2D1SCN5A | |
| SCHEMBL27715058 | 0.67 | CHRNA7 (0.47) | TDP2ABL1BCR | |
| SCHEMBL24121907 | 0.67 | ADORA2A (0.34) | — | |
| SCHEMBL21434020 | 0.66 | CACNA2D1 (0.47) | SLC34A1CACNA2D1SCN5AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814885-A2 | NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006073610-A2 | NOVEL BICYCLIC HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |