SCHEMBL5366245

SCHEMBL5366245

[O]C(=O)c1cc2ccccc2o1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 2/20 0.74
NPC1 O15118 7/20 0.65
RAB9A P51151 6/20 0.65
MAPK1 P28482 3/20 0.65
TSHR P16473 2/20 0.65
MEN1 O00255 1/20 0.65
KMT2A Q03164 1/20 0.65
SMN1; SMN2 Q16637 5/20 0.59
TP53 P04637 2/20 0.59
PKM P14618 1/20 0.59
NFKB1 P19838 1/20 0.59
NFKB2 Q00653 1/20 0.59
RELA Q04206 1/20 0.59
MAPT P10636 6/20 0.57
ALDH1A1 P00352 6/20 0.57
HPGD P15428 5/20 0.57
POLB P06746 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.56
STK17B O94768 1/20 0.56
ALOX15 P16050 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31061078 0.85 FLT3 (1.00) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL244107 0.85 FLT3 (1.00) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL155789 0.83 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
Benzene SCHEMBL28107977 0.83 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL29460209 0.83 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL649402 0.83 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL29496924 0.83 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
Hydrochloric Acid SCHEMBL5981164 0.82 FLT3 (0.71) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL5309787 0.82 FLT3 (0.71) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL557778 0.82 FLT3 (0.71) FLT3NPC1RAB9AMAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006138589-A2 OPIOID RECEPTOR LIGANDS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2006-12-28 WO claimed
EP-4371979-A1 FORMAMIDE DERIVATIVE AND AGRICULTURAL OR HORTICULTURAL PLANT DISEASE CONTROL AGENT Kumiai Chemical Industry Co., Ltd. (JP) 2024-05-22 EP disclosed
CN-117693500-A Carboxamide derivative and agricultural/horticultural plant disease control agent 组合化学工业株式会社 2024-03-12 CN disclosed
CN-116836154-A Compounds useful for gout 江苏新元素医药科技有限公司 2023-10-03 CN disclosed
WO-2023286855-A1 FORMAMIDE DERIVATIVE AND AGRICULTURAL OR HORTICULTURAL PLANT DISEASE CONTROL AGENT クミアイ化学工業株式会社 2023-01-19 WO disclosed
US-7217723-B2 Substituted benzothiophenes, e.g., 7Z)-7-hydroxyimino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)-2-hydroxyethyl]-methyl-amide; treating allergies such as atopic dermatitis, allergic coryza, bronchial asthma, hypersensitive pneumoniac and pulmonary aspergillosis. EISAI CO., LTD. (JP) 2007-05-15 US disclosed
US-20050227959-A1 Heterocyclic compound having oxime group EISAI CO., LTD. (JP) 2005-10-13 US disclosed
US-4009038-A CYAN COUPLER, A 2-(2'-HYDROXYPHENYL)BENZOTRIAZOLE FUJI PHOTO FILM CO., LTD. (JA) 1977-02-22 US disclosed
US-3935015-A Silver halide color photographic materials containing 3-anilino-5-pyrazolane couplers FUJI PHOTO FILM CO., LTD. (JA) 1976-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050227959-A1 Heterocyclic compound having oxime group STAT6, HRH4, HRH2 FLT3 166/4885NPC1 4248/4885RAB9A 3907/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.