Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 0.79 |
| ▸ | RAB9A | P51151 | 5/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 4/20 | 0.69 |
| ▸ | STK17B | O94768 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31061078 | 1.00 | FLT3 (1.00) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL3263663 | 0.88 | NPC1 (1.00) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL244128 | 0.88 | FLT3 (0.83) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL30629236 | 0.88 | FLT3 (0.77) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL29848549 | 0.86 | FLT3 (0.74) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL29460209 | 0.85 | FLT3 (0.74) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL155789 | 0.85 | FLT3 (0.74) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL5366245 | 0.85 | FLT3 (0.74) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL649402 | 0.85 | FLT3 (0.74) | FLT3NPC1RAB9AMAPK1TSHR | |
| SCHEMBL29496924 | 0.85 | FLT3 (0.74) | FLT3NPC1RAB9AMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1318417-C | Double ketole colorless benzofuryl ketone compound and its preparation | DONGBEI UNIVERSITY (CN) | 2007-05-30 | — | — | CN | claimed |
| CN-1680369-A | Double ketole colorless benzofuryl ketone compound and its preparation | UNIV DONGBEI (CN) | 2005-10-12 | — | — | CN | claimed |
| JP-60036476-A | — | — | None | — | — | JP | disclosed |
| JP-59206378-A | — | — | None | — | — | JP | disclosed |
| EP-3668867-B1 | SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS | UNIV REGENSBURG (DE) | 2023-10-04 | — | — | EP | disclosed |
| US-11584717-B2 | MIF modulators | YALE UNIVERSITY (US) | 2023-02-21 | — | — | US | disclosed |
| US-11384076-B2 | Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors | UNIVERSITÄT REGENSBURG (DE) | 2022-07-12 | — | — | US | disclosed |
| US-20200377457-A1 | MIF MODULATORS | UNIV YALE (US) | 2020-12-03 | — | — | US | disclosed |
| US-20200377457-A1 | MIF MODULATORS | UNIV YALE (US) | 2020-12-03 | — | — | US | disclosed |
| EP-3668867-A1 | SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS | Universität Regensburg (DE) | 2020-06-24 | — | — | EP | disclosed |
| US-20200190075-A1 | SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS | UNIVERSITÄT REGENSBURG (DE) | 2020-06-18 | — | — | US | disclosed |
| US-20030148216-A1 | Dye for optical recording medium | RITEK CORPORATION (TW) | 2003-08-07 | — | — | US | disclosed |
| US-6589984-B1 | Blood cholesterol and triglycerides (TG) themselves are generally insoluble in blood, and they exist as lipoproteins by binding with apolipoproteins. In the body, triglycerides are biosynthesized primarily in the liver from acetyl CoA as | TEIJIN LIMITED (JP) | 2003-07-08 | — | — | US | disclosed |
| EP-1063235-A1 | BENZOFURYLPYRONE DERIVATIVES | TEIJIN LIMITED (JP) | 2000-12-27 | — | — | EP | disclosed |
| EP-0778274-A1 | Amidinohydrazones of ketones derived from benzo(b)furan, process for their preparation and medicaments containing these compounds | Helopharm G. Petrik GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| JP-S6036476-A | NOVEL BISBENZOFURANYL KETONE DERIVATIVE AND ITS PRODUCTION | KAKEN PHARMACEUT CO LTD | 1985-02-25 | — | — | JP | disclosed |
| JP-S59206378-A | BISBENZOFURANYL KETONE DERIVATIVE AND ITS PREPARATION | KAKEN PHARMACEUT CO LTD | 1984-11-22 | — | — | JP | disclosed |
| EP-0020391-A1 | SUBSTITUTED ACETIC ACID ESTERS | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1981-01-07 | — | — | EP | disclosed |
| WO-1980000563-A1 | SUBSTITUTED ACETIC ACID ESTERS | SOREX LTD (GB) | 1980-04-03 | — | — | WO | disclosed |
| US-4001426-A | HAVING CORONARY VASODILATOR ACTIVITY | SMITHKLINE CORPORATION (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584717-B2 | MIF modulators | MIF, HMGB2, HMGB3 | FLT3 506/4885NPC1 1815/4885RAB9A 4603/4885 |
| US-11384076-B2 | Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors | FLT3, CSF3R, ABL1 | FLT3 1/4885NPC1 3493/4885RAB9A 4286/4885 |
| US-20200377457-A1 | MIF MODULATORS | MIF, HMGB2, HMGB3 | FLT3 506/4885NPC1 1815/4885RAB9A 4603/4885 |
| US-20200190075-A1 | SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS | FLT3, CSF3R, ABL1 | FLT3 1/4885NPC1 3493/4885RAB9A 4286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.