SCHEMBL557778

SCHEMBL557778

O=C(Cl)c1cc2ccccc2o1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 2/20 0.71
NPC1 O15118 7/20 0.62
RAB9A P51151 7/20 0.62
MAPK1 P28482 3/20 0.62
TSHR P16473 2/20 0.62
MEN1 O00255 1/20 0.62
KMT2A Q03164 1/20 0.62
SMN1; SMN2 Q16637 5/20 0.57
TP53 P04637 2/20 0.57
PKM P14618 1/20 0.57
NFKB1 P19838 1/20 0.57
NFKB2 Q00653 1/20 0.57
RELA Q04206 1/20 0.57
MAPT P10636 6/20 0.56
ALDH1A1 P00352 4/20 0.56
HPGD P15428 4/20 0.56
POLB P06746 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.54
STK17B O94768 1/20 0.54
ALOX15 P16050 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL244107 0.83 FLT3 (1.00) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL31061078 0.83 FLT3 (1.00) FLT3NPC1RAB9AMAPK1TSHR
Benzene SCHEMBL28107977 0.82 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL29460209 0.82 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL649402 0.82 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL155789 0.82 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL5366245 0.82 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL29496924 0.82 FLT3 (0.74) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL11257047 0.80 FLT3 (0.61) FLT3NPC1RAB9AMAPK1TSHR
SCHEMBL5309787 0.80 FLT3 (0.71) FLT3NPC1RAB9AMAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 353 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116253676-A Amide compound, polymer film containing amide compound, and preparation method and application of polymer film 中国科学院理化技术研究所 2023-06-13 CN claimed
US-20160368902-A1 CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF SARCODE BIOSCIENCE INC. (US) 2016-12-22 US claimed
US-8080562-B2 Crystalline pharmaceutical and methods of preparation and use thereof SARCODE BIOSCIENCE INC. (US) 2011-12-20 US claimed
US-20090298869-A1 Crystalline pharmaceutical and methods of preparation and use thereof CITIBANK, N.A., AS NOTES COLLATERAL AGENT 2009-12-03 US claimed
WO-2009139817-A2 CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF SARCODE CORPORATION (US) 2009-11-19 WO claimed
EP-1713790-A2 METHOD OF PREPARATION OF BENZOFURAN-2-CARBOXYLIC ACID (S)-3-METHYL-1- ((4S, 7R)-7METHYL-3-OXO-1-(PYRIDINE-2-SULFONYL)-AZ EPAN-4-YLCARBAMOYL-BUTYL)-AMIDE SMITHKLINE BEECHAM CORPORATION (US) 2006-10-25 EP claimed
WO-2005069981-A2 METHOD OF PREPARATION OF BENZOFURAN-2-CARBOXYLIC ACID {(S)-3-METHYL-1-[(4S, 7R)-7METHYL-3-OXO-1-(PYRIDINE-2-SULFONYL)-AZEPAN-4-YLCARBAMOYL]-BUTYL}-AMIDE SMITHKLINE BEECHAM CORPORATION (US) 2005-08-04 WO claimed
WO-2026107377-A1 PHARMACOLOGICAL RE-ACTIVATION OF MUTANT PVHL KARANICOLAS JOHN (US) 2026-05-21 WO disclosed
US-20260070903-A1 NOVEL PYRIDO[3,4-D]PYRIMIDIN-8-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, COMPRISING SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-03-12 US disclosed
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2025-08-07 US disclosed
US-20250074925-A1 RARE EARTH COMPLEX SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) 2025-03-06 US disclosed
US-20250034164-A1 NOVEL COMPOUND AND COMPOSITION FOR PREVENTING OR TREATING NEUROINFLAMMATORY BRAIN DISEASES COMPRISING SAME AS ACTIVE INGREDIENT KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KR) 2025-01-30 US disclosed
US-20250011308-A1 CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT 2025-01-09 US disclosed
US-4414389-A 4-Substituted-piperidino carboxamides AMERICAN HOME PRODUCTS CORPORATION (US) 1983-11-08 US disclosed
US-4269846-A BENZOHETEROCYCLIC OXADIAZOLONES AND TRIAZOLONES USV PHARMACEUTICAL CORPORATION (US) 1981-05-26 US disclosed
US-4267174-A AND PROCESS FOR ADMINISTERING BOEHRINGER MANNHEIM, GMBH (DE) 1981-05-12 US disclosed
US-4255585-A HYPOTENSIVE, DIURETIC CENTRE EUROPEAN DE RECHERCHES PHARMACOLOGIQUE (FR) 1981-03-10 US disclosed
US-3996359-A ANTIINFLAMMATORY AB BOFORS (SW) 1976-12-07 US disclosed
US-3992534-A Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods AB BOFORS (SW) 1976-11-16 US disclosed
US-3983233-A ANTIINFLAMMATORY AB BOFORS (SW) 1976-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250034164-A1 NOVEL COMPOUND AND COMPOSITION FOR PREVENTING OR TREATING NEUROINFLAMMATORY BRAIN DISEASES COMPRISING SAME AS ACTIVE INGREDIENT FABP7, BDNF, PSEN1 FLT3 4783/4885NPC1 142/4885RAB9A 2730/4885
US-20250011308-A1 CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF VCAM1, ICAM1, HLA-DRB1 FLT3 1635/4885NPC1 355/4885RAB9A 1157/4885
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 FLT3 4720/4885NPC1 319/4885RAB9A 913/4885
US-20160368902-A1 CRYSTALLINE PHARMACEUTICAL AND METHODS OF PREPARATION AND USE THEREOF VCAM1, ICAM1, HLA-DRB1 FLT3 1635/4885NPC1 355/4885RAB9A 1157/4885
US-20090298869-A1 Crystalline pharmaceutical and methods of preparation and use thereof VCAM1, ICAM1, HLA-DRB1 FLT3 1635/4885NPC1 355/4885RAB9A 1157/4885
US-20250074925-A1 RARE EARTH COMPLEX L1CAM, CHRM1, NPM1 FLT3 93/4885NPC1 1197/4885RAB9A 2697/4885
US-20260070903-A1 NOVEL PYRIDO[3,4-D]PYRIMIDIN-8-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, COMPRISING SAME CCNC, CKS1B, CKS2 FLT3 951/4885NPC1 811/4885RAB9A 972/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.