Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.63 |
| ▸ | RARB | P10826 | 5/20 | 0.63 |
| ▸ | RARG | P13631 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.62 |
| ▸ | GOT1 | P17174 | 1/20 | 0.62 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL565789 | 0.89 | RARA (0.77) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL7689498 | 0.89 | RARA (0.67) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL1082340 | 0.89 | RARA (0.77) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL8398374 | 0.89 | RARA (0.53) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL9493164 | 0.89 | RARA (0.63) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL9334071 | 0.88 | RARB (0.83) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL566278 | 0.87 | RARA (0.62) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL8776353 | 0.87 | RARA (0.62) | RARARARBRARGKMT2AMEN1 | |
| SCHEMBL9492280 | 0.87 | RARA (0.62) | RARARARBRARGKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9124255 | 0.87 | RARA (0.76) | RARARARBRARGKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259187-B2 | Tropolone derivatives | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2007-08-21 | — | — | US | disclosed |
| US-20040082550-A1 | Tropolone derivative | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1357104-A1 | TROPOLONE DERIVATIVE | Research Foundation Itsuu Laboratory (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-6194450-B1 | KERATINIZATION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-02-27 | — | — | US | disclosed |
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| US-5869067-A | TREATING DERMATOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1999-02-09 | — | — | US | disclosed |
| US-5849798-A | Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5786379-A | Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-07-28 | — | — | US | disclosed |
| US-5753239-A | Bi-aromatic compounds and pharmaceutical and cosmetic compositions | CENTRE INTERNATIONAL DE RECHERCHES DEMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1998-05-19 | — | — | US | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5260295-A | Retinoic acid derivatives, cosmetics, skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5212203-A | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOGOLOGIQUES (C.I.R.D.) (FR) | 1993-05-18 | — | — | US | disclosed |
| US-5200550-A | Administering for dermatologic, rheumatismal, respiratory or ophthalomologic disorders | CENTRE INTERNATIONAL DE RECHERCES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1993-04-06 | — | — | US | disclosed |
| WO-1993006086-A1 | RETINOIDS AND THEIR USE IN TREATING SKIN DISEASES AND LEUKEMIA | PFIZER INC. (US) | 1993-04-01 | — | — | WO | disclosed |
| US-5173289-A | Skin disorders, antiinflammatory agents | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1992-12-22 | — | — | US | disclosed |
| US-5059621-A | Treatment of dermatologic ailments linked to keratinization disorder | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1991-10-22 | — | — | US | disclosed |
| US-4927928-A | SKIN DISORDERS, EYES, ANTITUMOR | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1990-05-22 | — | — | US | disclosed |
| US-4925658-A | TREATMENT OF DERMATOLOGIC, RHEUMATIC, RESPIRATORY, OPHTHALMOLOGIC DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1990-05-15 | — | — | US | disclosed |
| US-4920140-A | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1990-04-24 | — | — | US | disclosed |
| US-4740519-A | Benzo (b) thiophene carboxylate derivatives and pharmaceutical compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1988-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082550-A1 | Tropolone derivative | NR5A2, NR0B1, MTNR1A | RARA 41/4885RARB 73/4885RARG 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.