Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10963680 | 0.84 | KDM4E (0.42) | KDM4EALDH1A1PKMSMN1; SMN2GAA | |
| SCHEMBL6755827 | 0.81 | KDM4E (0.57) | KDM4EALDH1A1PKMSMN1; SMN2GAA | |
| SCHEMBL22633135 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1PKMSMN1; SMN2GAA | |
| SCHEMBL16548434 | 0.78 | MAPK1 (0.53) | ALDH1A1MAPK1HTR2C | |
| SCHEMBL2340816 | 0.78 | — | — | |
| SCHEMBL18250248 | 0.77 | MAPK1 (0.36) | ALDH1A1SMN1; SMN2GAAPOLBTP53 | |
| SCHEMBL20197195 | 0.77 | ALDH1A1 (0.33) | ALDH1A1GAAHTTMEN1MAPT | |
| SCHEMBL16544521 | 0.76 | ALDH1A1 (0.33) | ALDH1A1TLR7POLBTP53HTT | |
| SCHEMBL10725199 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1PKMSMN1; SMN2GAA | |
| SCHEMBL16815514 | 0.74 | MAPK1 (0.34) | ALDH1A1GAAHTTMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070130702-A1 | Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative | L'OREAL S.A. | 2007-06-14 | — | — | US | claimed |
| US-20070130702-A1 | Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative | L'OREAL S.A. | 2007-06-14 | — | — | US | disclosed |
| US-7204857-B1 | Dyeing method using a specific active methylene compound and a compound selected among a specific aldehyde, a specific ketone, a quinone and a di-imino-isoindoline or 3-amino-isoindolone derivative | L'OREAL S.A. (FR) | 2007-04-17 | — | — | US | disclosed |
| US-20050262647-A1 | Agent for dyeing fibers containing keratin | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2005-12-01 | — | — | US | disclosed |
| EP-1056433-B1 | DYEING METHOD USING A SPECIFIC ACTIVE METHYLENE COMPOUND AND A COMPOUND SELECTED AMONG A SPECIFIC ALDEHYDE, A SPECIFIC KETONE, A QUINONE AND A DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVE | OREAL (FR) | 2005-05-11 | — | — | EP | disclosed |
| EP-1056433-A1 | DYEING METHOD USING A SPECIFIC ACTIVE METHYLENE COMPOUND AND A COMPOUND SELECTED AMONG A SPECIFIC ALDEHYDE, A SPECIFIC KETONE, A QUINONE AND A DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVE | L'OREAL (FR) | 2000-12-06 | — | — | EP | disclosed |
| WO-2000038638-A1 | DYEING METHOD USING A SPECIFIC ACTIVE METHYLENE COMPOUND AND A COMPOUND SELECTED AMONG A SPECIFIC ALDEHYDE, A SPECIFIC KETONE, A QUINONE AND A DI-IMINO-ISOINDOLINE OR 3-AMINO-ISOINDOLONE DERIVATIVE | L'OREAL (FR) | 2000-07-06 | — | — | WO | disclosed |
| US-4645838-A | Pyrazolopyridine compounds, and intermediates, useful as anxiolytic agents | ICI AMERICAS INC. (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0094175-B1 | PYRAZOLOPYRIDINE COMPOUNDS | ICI AMERICAS INC. (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4563525-A | Process for preparing pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1986-01-07 | — | — | US | disclosed |
| US-4552883-A | CNS DEPRESSANTS, ANXIOLYTICS | ICI AMERICAS INC. (US) | 1985-11-12 | — | — | US | disclosed |
| US-4511568-A | CNS-Depressant pyrazolopyridines | ICI AMERICAS INC. (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0096995-A2 | Pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1983-12-28 | — | — | EP | disclosed |
| EP-0094175-A1 | Pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1983-11-16 | — | — | EP | disclosed |
| US-4375467-A | 5-(Pyridinyl)-1H-pyrazolo[3,4-b] pyridines and their cardiotonic use | STERLING DRUG INC. (US) | 1983-03-01 | — | — | US | disclosed |
| US-4246410-A | BENZINDOLE DYES OF YELLOW AND RED | CIBA -GEIGY AKTIENGESELLSCHAFT (CH) | 1981-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070130702-A1 | Dyeing process using a specific compound containing active methylene and a compound chosen from a specific aldehyde, a specific ketone, a quinone and a diiminoisoindoline or 3-aminoisoindolone derivative | KRT18, NDUFB5, NDUFB7 | KDM4E 440/4885ALDH1A1 83/4885PKM 196/4885 |
| US-20050262647-A1 | Agent for dyeing fibers containing keratin | KRT18, CKAP4, KRTCAP2 | KDM4E 1076/4885ALDH1A1 240/4885PKM 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.