Sugi Predict

Sugi Predict / Compounds / SCHEMBL5366471

SCHEMBL5366471

SCHEMBL5366471

Cc1nc2c(Oc3ccccc3)nc3c(c2n1CCCCS(=O)(=O)c1ccc(F)cc1)CCCC3

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ HTR2A P28223 1/20 0.35
▸ MMP1 P03956 1/20 0.34
▸ MMP3 P08254 1/20 0.34
▸ MMP8 P22894 1/20 0.34
▸ MMP13 P45452 1/20 0.34
▸ BCHE P06276 4/20 0.34
▸ SCARB1 Q8WTV0 1/20 0.33
▸ HTR7 P34969 1/20 0.32
▸ POLB P06746 3/20 0.32
▸ PTGDR2 Q9Y5Y4 2/20 0.31
▸ LMNA P02545 1/20 0.31
▸ NR1H2 P55055 1/20 0.31
▸ NR1H3 Q13133 1/20 0.31
▸ ACHE P22303 1/20 0.31
▸ FFAR1 O14842 1/20 0.31
▸ MAPK13 O15264 1/20 0.30
▸ MAPK12 P53778 1/20 0.30
▸ MAPK11 Q15759 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5355562 0.84 BCHE (0.32) HTTBCHEPOLBLMNAACHE
SCHEMBL5406199 0.84 BCHE (0.32) HTTBCHEPOLBLMNAACHE
SCHEMBL5367276 0.83 HTR2A (0.38) SMN1; SMN2HTR2ABCHESCARB1POLB
SCHEMBL5368947 0.81 BCHE (0.36) HTTBCHELMNAACHE
SCHEMBL5348190 0.77 NPC1 (0.32) HTTBCHELMNAACHE
SCHEMBL6477156 0.76 HTT (0.33) HTTSMN1; SMN2BCHEPOLBPTGDR2
SCHEMBL5350391 0.74 TLR8 (0.36) BCHEACHE
SCHEMBL6483879 0.73 ACHE (0.33) SMN1; SMN2BCHEPOLBACHECYP1A2
SCHEMBL6700923 0.71 MAPT (0.36) BCHEACHE
SCHEMBL6726135 0.68 LMNA (0.34) HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7276515-B2 Thioether substituted imidazoquinolines COLEY PHARMACEUTICAL GROUP, INC. (US) 2007-10-02 — — US disclosed
US-6949649-B2 Thioether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES CO. (US) 2005-09-27 — — US disclosed
US-20050209268-A1 Thioether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2005-09-22 — — US disclosed
EP-1451191-A1 THIOETHER SUBSTITUTED IMIDAZOQUINOLINES 3M Innovative Properties Company (US) 2004-09-01 — — EP disclosed
US-6667312-B2 Useful as immune response modifiers 3M INNOVATIVE PROPERTIES COMPANY 2003-12-23 — — US disclosed
WO-2003050121-A1 THIOETHER SUBSTITUTED IMIDAZOQUINOLINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2003-06-19 — — WO disclosed
US-20030100764-A1 Thioether substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2003-05-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050209268-A1 Thioether substituted imidazoquinolines IFNG, IRF3, IL2 HTT 3552/4885SMN1; SMN2 3375/4885HTR2A 4695/4885
US-20030100764-A1 Thioether substituted imidazoquinolines IFNG, IRF3, IL2 HTT 3552/4885SMN1; SMN2 3375/4885HTR2A 4695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.