Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.43 |
| ▸ | PGR | P06401 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764090 | 0.91 | HIF1A (0.62) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL3764086 | 0.91 | HIF1A (0.62) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL6565563 | 0.89 | HSD17B10 (0.57) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL3700732 | 0.89 | HSD17B10 (0.57) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL5180250 | 0.89 | HSD17B10 (0.57) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL6564776 | 0.84 | PGR (0.60) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL6564780 | 0.84 | PGR (0.60) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL5697443 | 0.80 | LMNA (0.51) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL26133329 | 0.80 | LMNA (0.51) | NR3C1HIF1ALMNAMEN1KMT2A | |
| SCHEMBL6566615 | 0.79 | NR3C1 (0.65) | NR3C1HIF1ALMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414375-A1 | NOVEL AMIDE DERIVATIVES OF STEROIDALÝ3,2-C¨PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | AstraZeneca AB (SE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114471-A1 | NOVEL AMIDE DERIVATIVES OF STEROIDAL[3,2-C]PYRAZOLE COMPOUNDS WITH GLUCOCORTICOID ACTIVITY | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | WO | disclosed |