Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | APAF1 | O14727 | 2/20 | 0.38 |
| ▸ | GALK1 | P51570 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HK1 | P19367 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 3/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30997931 | 1.00 | MAPT (0.38) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL28672198 | 0.82 | — | — | |
| SCHEMBL4555851 | 0.72 | IDO1 (0.37) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3348606 | 0.69 | MAOA (0.38) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL30804593 | 0.69 | MAOA (0.38) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL4515365 | 0.69 | IDO1 (0.54) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL1899659 | 0.68 | MAPT (0.37) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL8690288 | 0.67 | MEN1 (0.59) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL21316073 | 0.66 | MEN1 (0.63) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL28418546 | 0.66 | MAPT (0.40) | MAPTKMT2ALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864089-B | Indolopyridone drug molecule and preparation method and application thereof | 日照巴洛特药业有限公司 | 2020-01-10 | — | — | CN | claimed |
| EP-3684767-B1 | HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS | Jubilant Epipad LLC (US) | 2024-04-24 | — | — | EP | disclosed |
| CN-113861193-A | Method for preparing indolopyridyl tetralone and derivatives thereof by photoinitiated free radical series reaction and products | 西南大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-108864089-B | Indolopyridone drug molecule and preparation method and application thereof | 日照巴洛特药业有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-108864089-B | Indolopyridone drug molecule and preparation method and application thereof | 日照巴洛特药业有限公司 | 2020-01-10 | — | — | CN | disclosed |
| CN-108864089-B | Indolopyridone drug molecule and preparation method and application thereof | 日照巴洛特药业有限公司 | 2020-01-10 | — | — | CN | disclosed |
| US-8513205-B2 | Potent chimeric NRTI-NNRTI bifunctional inhibitors of HIV-1 reverse transcriptase | YALE UNIVERSITY (US) | 2013-08-20 | — | — | US | disclosed |
| US-8410144-B2 | Substituted indolo-pyridinone compounds | ARQULE, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410144-B2 | Substituted indolo-pyridinone compounds | ARQULE, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410144-B2 | Substituted indolo-pyridinone compounds | ARQULE, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2414344-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| EP-2414344-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20110312880-A1 | POTENT CHIMERIC NRTI-NNRTI BIFUNCTIONAL INHIBITORS OF HIV-1 REVERSE TRANSCRIPTASE | ANDERSON KAREN S (US) | 2011-12-22 | — | — | US | disclosed |
| WO-2011073959-A2 | CRYSTAL STRUCTURE OF THE HIV-1 REVERSE TRANSCRIPTASE BOUND TO A NUCLEOTIDE-COMPETITIVE REVERSE TRANSCRIPTASE INHIBITOR AND THE USE THEREOF | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2011-06-23 | — | — | WO | disclosed |
| WO-2010114896-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114896-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| WO-2009126293-A2 | POTENT CHIMERIC NRTI-NNRTI BIFUNCTIONAL INHIBITORS OF HIV-1 REVERSE TRANSCRIPTASE | YALE UNIVERSITY (US) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312880-A1 | POTENT CHIMERIC NRTI-NNRTI BIFUNCTIONAL INHIBITORS OF HIV-1 REVERSE TRANSCRIPTASE | NAMPT, NAPRT, DNTT | MAPT 314/4885MEN1 4826/4885KMT2A 199/4885 |
| US-20100249127-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | MKI67, CCNI, CDK4 | MAPT 1367/4885MEN1 788/4885KMT2A 2288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.