Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31497268 | 0.85 | ALDH1A1 (0.45) | ALDH1A1LMNASMN1; SMN2CYP1A2TSHR | |
| SCHEMBL8615002 | 0.85 | ESR1 (0.40) | TAAR1ESR1S1PR1ALDH1A1LMNA | |
| SCHEMBL23800848 | 0.83 | HTR2A (0.36) | TAAR1ESR1S1PR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10799818 | 0.81 | ESR1 (0.44) | TAAR1ESR1S1PR1ALDH1A1LMNA | |
| SCHEMBL10589998 | 0.80 | CYP2C19 (0.41) | ESR1S1PR1ALDH1A1LMNATP53 | |
| SCHEMBL11788444 | 0.79 | S1PR1 (0.38) | ESR1S1PR1ALDH1A1LMNATP53 | |
| SCHEMBL24730244 | 0.79 | TRPM8 (0.43) | TAAR1ESR1S1PR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11794334 | 0.79 | ESR1 (0.31) | ESR1S1PR1 | |
| SCHEMBL20689739 | 0.78 | TAAR1 (0.41) | TAAR1ESR1ALDH1A1LMNATP53 | |
| SCHEMBL11396356 | 0.77 | ESR1 (0.40) | ESR1S1PR1ALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150025063-A1 | Antiparkinsonian Action of Phenylisopropylamines | UNIV DUKE (US) | 2015-01-22 | — | — | US | disclosed |
| US-8877802-B2 | Antiparkinsonian action of phenylisopropylamines | Duke Univerity (US) | 2014-11-04 | — | — | US | disclosed |
| WO-2007016190-A2 | ANTIPARKINSONIAN ACTION OF PHENYLISOPROPYLAMINES | DUKE UNIVERSITY (US) | 2007-02-08 | — | — | WO | disclosed |
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-02-01 | — | — | US | disclosed |
| US-7026429-B2 | Hydrophilic polyurethane-polyurea dispersions | BAYER AKTIENGESELLSCHAFT (DE) | 2006-04-11 | — | — | US | disclosed |
| US-20050176883-A1 | Hydrophilic polyurethane-polyurea dispersions | BAYER AKTIENGESELLSCHAFT (DE) | 2005-08-11 | — | — | US | disclosed |
| US-6784243-B2 | COMPRISES N-TERT-BUTYLBENZYLAMINE AS BLOCKING AGENT; FOR GLASS FIBERS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-08-31 | — | — | US | disclosed |
| US-20030232199-A1 | Polyurethane-polyurea dispersions | COVESTRO DEUTSCHLAND AG (DE) | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027208-A1 | Antiparkinsonian Action of Phenylisopropylamines | PNMT, SNCA, COMT | TAAR1 1075/4885ESR1 4627/4885S1PR1 962/4885 |
| US-20150025063-A1 | Antiparkinsonian Action of Phenylisopropylamines | PNMT, SNCA, COMT | TAAR1 1075/4885ESR1 4627/4885S1PR1 962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.